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Antimicrobial Agents and Chemotherapy, May 2001, p. 1565-1567, Vol. 45, No. 5
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.5.1565-1567.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Vancomycin and Ceftazidime Bioactivities Persist for at Least 2 Weeks in the Lumen in Ports: Simplifying Treatment of Port-Associated Bloodstream Infections by Using the Antibiotic Lock Technique

Yishai Haimi-Cohen,1 Neghma Husain,2 Jerry Meenan,3 Gungor Karayalcin,2 Michael Lehrer,3 and Lorry G. Rubin1,*

Divisions of Infectious Diseases1 and Hematology-Oncology,2 Department of Pediatrics, Schneider Children's Hospital, and Department of Pathology,3 Long Island Jewish Medical Center of the North Shore-Long Island Jewish Medical Center Health System, Albert Einstein College of Medicine, New Hyde Park, New York 11040

Received 14 August 2000/Returned for modification 13 January 2001/Accepted 8 February 2001

The residual antibiotic concentration of vancomycin (2 mg/ml)- or ceftazidime (2 mg/ml)-heparin solutions instilled in ports in pediatric hematology-oncology patients 1 to 34 days earlier was measured. Antibiotic concentrations of >= 100 µg of either antibiotic per ml persisted for at least 21 days. For treatment of lumenal port infections, antibiotic-heparin dwell times of >= 2 weeks may be appropriate.

* Corresponding author. Mailing address: Schneider Children's Hospital, 269-01 76th Ave., New Hyde Park, NY 11040. Phone: (718) 470-3480. Fax: (718) 470-0887. E-mail: lrubin{at}lij.edu.

Antimicrobial Agents and Chemotherapy, May 2001, p. 1565-1567, Vol. 45, No. 5
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.5.1565-1567.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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