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Antimicrobial Agents and Chemotherapy, May 2001, p. 1581-1584, Vol. 45, No. 5
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.5.1581-1584.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Antimicrobial Susceptibilities of Unique Stenotrophomonas maltophilia Clinical Strains

Sylvia Valdezate,1,2 Ana Vindel,2 Elena Loza,1 Fernando Baquero,1 and Rafael Cantón1,*

Servicio de Microbiología, Hospital Ramón y Cajal, Madrid-28034,1 and Laboratorio de Infecciones Intrahospitalarias, Centro Nacional de Microbiología. Instituto Carlos III, Majadahonda, Madrid-28220,2 Spain

Received 5 September 2000/Returned for modification 29 January 2001/Accepted 21 February 2001

Susceptibility to 41 antimicrobials was studied with 99 Stenotrophomonas maltophilia strains, and different pulsed-field gel electrophoresis profiles were identified among 130 prospectively collected isolates. Moxalactam, doxycycline, minocycline, and clinafloxacin displayed the highest activity (>= 98% susceptibility). Ticarcillin resistance (75%) was reverted by clavulanate in 25% of strains. Trimethoprim-sulfamethoxazole resistance was 26.2% (>= 4 [trimethoprim]/76 [sulfamethoxazole] µg/ml) and dropped to 11.1% when an 8/152-µg/ml breakpoint was applied based on its bimodal MIC distribution. Resistance was lower when unique strains were considered, because clonal organisms contribute to resistance.

* Corresponding author. Mailing address: Servicio de Microbiología. Hospital Ramón y Cajal, Carretera de Colmenar, Km 9,100. 28034-Madrid. Spain. Phone: 34-91-3368330. Fax: 34-91-3368809. E-mail: rcanton{at}hrc.insalud.es.

Antimicrobial Agents and Chemotherapy, May 2001, p. 1581-1584, Vol. 45, No. 5
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.5.1581-1584.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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