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Antimicrobial Agents and Chemotherapy, May 2001, p. 1591-1594, Vol. 45, No. 5
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.5.1591-1594.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Prevention and Treatment of Lethal Murine Endotoxemia by the Novel Immunomodulatory Agent MFP-14

Ferdinando Nicoletti,1,* Roberto Di Marco,2 Paola Sacerdote,3 PierLuigi Meroni,4 Katia Mangano,2 Carl Edwards III,5 Alberto Bartorelli,6 Klaus Bendtzen,7 and Alberto Panerai3

Department of Clinical Medicine, Prevention and Biotechnological Health, University of Milan Bicocca,1 Department of Pharmacology3 and Institute of Research Giorgio Sisini,6 University of Milan, and Istituto Auxologico IRCCS,4 Milan, and Department of Microbiological and Gynaecological Sciences, University of Catania, Catania,2 Italy; Amgen Inc., Thousand Oaks, California5; and Institute for Inflammation Research, National University Hospital, Copenhagen, Denmark7

Received 6 October 2000/Returned for modification 29 December 2000/Accepted 5 February 2001

Multifunctional protein 14 (MFP-14) is a ubiquitous protein that inhibits the production of tumor necrosis factor alpha (TNF-alpha ) and gamma interferon (IFN-gamma ), which are involved in the pathogenesis of sepsis. Here, lipopolysaccharide (LPS)-induced lethality in mice was markedly reduced by MFP-14. The treatment also lowered LPS-induced levels of TNF-alpha and IFN-gamma in the blood.

* Corresponding author. Mailing address: Via Luigi Sturzo n. 3, 95021, Cannizzaro, Catania, Italy. Phone: 39-347-3369125. Fax: 39-095-325032. E-mail: ferdinic{at}ctonline.it.

Antimicrobial Agents and Chemotherapy, May 2001, p. 1591-1594, Vol. 45, No. 5
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.5.1591-1594.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.




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