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Antimicrobial Agents and Chemotherapy, May 2001, p. 1595-1598, Vol. 45, No. 5
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.5.1595-1598.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Serotype 19F Multiresistant Pneumococcal Clone Harboring Two Erythromycin Resistance Determinants [erm(B) and mef(A)] in South Africa

Lesley McGee,1,* Keith P. Klugman,1 Avril Wasas,1 Thora Capper,1 Adrian Brink,2 and The Antibiotics Surveillance Forum Of South Africa

MRC/SAIMR/WITS Pneumococcal Diseases Research Unit, South African Institute for Medical Research,1 and Drs DuBuisson, Bruinette and Partners,2 Johannesburg, South Africa

Received 12 October 2000/Returned for modification 30 November 2000/Accepted 24 January 2001

One hundred eighteen erythromycin-resistant Streptococcus pneumoniae (ERSP) strains (MICs of >= 0.5 µg/ml) from five laboratories serving the private sector in South Africa were analyzed for the genes encoding resistance to macrolides. Sixty-seven ERSP strains (56.8%) contained the erm(B) gene, and 15 isolates (12.7%) contained the mef(A) gene. Thirty-six isolates (30.5%) harbored both the erm(B) and mef(A) genes and were highly resistant to erythromycin and clindamycin. DNA fingerprinting by BOX-PCR and pulsed-field gel electrophoresis identified 83% of these strains as belonging to a single multiresistant serotype 19F clone.

* Corresponding author. Mailing address: Department of Clinical Microbiology and Infectious Diseases, South African Institute for Medical Research, P.O. Box 1038, Johannesburg 2000, South Africa. Phone: 27 11 489-9335. Fax: 27 11 489-9332. E-mail: lesmcgee{at}hotmail.com.

Antimicrobial Agents and Chemotherapy, May 2001, p. 1595-1598, Vol. 45, No. 5
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.5.1595-1598.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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