This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Pradines, B.
Right arrow Articles by Parzy, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pradines, B.
Right arrow Articles by Parzy, D.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, June 2001, p. 1746-1750, Vol. 45, No. 6
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.6.1746-1750.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

In Vitro Activities of Antibiotics against Plasmodium falciparum Are Inhibited by Iron

Bruno Pradines,* Christophe Rogier, Thierry Fusai, Joel Mosnier, William Daries, Eric Barret, and Daniel Parzy

Unité de Parasitologie, Institut de Médecine Tropicale du Service de Santé des Armées, Le Pharo, 13998 Marseille, France

Received 12 January 2001/Returned for modification 20 February 2001/Accepted 19 March 2001

The in vitro activities of cyclines (tetracycline, doxycycline, minocycline, oxytetracycline, and rolitetracycline), macrolides (erythromycin, spiramycin, roxithromycin, and lincomycin), quinolones (norfloxacin and ofloxacin), rifampin, thiamphenicol, tobramycin, metronidazole, vancomycin, phosphomycin, and cephalosporins (cephalexin, cefaclor, cefamandole, cefuroxime, ceftriazone, cefotaxime, and cefoxitin) were evaluated on Plasmodium falciparum clones, using an isotopic, micro-drug susceptibility test. Only tetracyclines, macrolides, quinolones, and rifampin demonstrated in vitro activity against P. falciparum, which increased after a prolonged exposure (96 or 144 h). In the presence of iron (FeCl3), only the activities of tetracyclines and norfloxacin were decreased. Their in vitro activity against intraerythrocytic stages of multidrug-resistant P. falciparum and their efficacy in vivo favor the use of antibiotics as antimalarial drugs. However, due to their slow antimalarial action and to the fact that they act better after prolonged contact, they probably need to be administered in conjunction with a rapidly acting antimalarial drug, such as a short course of chloroquine or quinine.

* Corresponding author. Mailing address: IMTSSA, Unité de Parasitologie, Bd Charles Livon, Parc le Pharo, BP 46, 13998 Marseille Armées, France. Phone: 33 4 91 15 01 10. Fax: 33 4 91 15 01 64. E-mail: bruno.pradines{at}free.fr.

Antimicrobial Agents and Chemotherapy, June 2001, p. 1746-1750, Vol. 45, No. 6
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.6.1746-1750.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Briolant, S., Baragatti, M., Parola, P., Simon, F., Tall, A., Sokhna, C., Hovette, P., Mamfoumbi, M. M., Koeck, J.-L., Delmont, J., Spiegel, A., Castello, J., Gardair, J. P., Trape, J. F., Kombila, M., Minodier, P., Fusai, T., Rogier, C., Pradines, B. (2009). Multinormal In Vitro Distribution Model Suitable for the Distribution of Plasmodium falciparum Chemosusceptibility to Doxycycline. Antimicrob. Agents Chemother. 53: 688-695 [Abstract] [Full Text]  
  • Dahl, E. L., Rosenthal, P. J. (2007). Multiple Antibiotics Exert Delayed Effects against the Plasmodium falciparum Apicoplast. Antimicrob. Agents Chemother. 51: 3485-3490 [Abstract] [Full Text]  
  • Prasad, T., Chandra, A., Mukhopadhyay, C. K., Prasad, R. (2006). Unexpected Link between Iron and Drug Resistance of Candida spp.: Iron Depletion Enhances Membrane Fluidity and Drug Diffusion, Leading to Drug-Susceptible Cells. Antimicrob. Agents Chemother. 50: 3597-3606 [Abstract] [Full Text]  
  • Dahl, E. L., Shock, J. L., Shenai, B. R., Gut, J., DeRisi, J. L., Rosenthal, P. J. (2006). Tetracyclines Specifically Target the Apicoplast of the Malaria Parasite Plasmodium falciparum.. Antimicrob. Agents Chemother. 50: 3124-3131 [Abstract] [Full Text]  
  • Pradines, B., Tall, A., Ramiandrasoa, F., Spiegel, A., Sokhna, C., Fusai, T., Mosnier, J., Daries, W., Trape, J. F., Kunesch, G., Parzy, D., Rogier, C. (2006). In vitro activity of iron-binding compounds against Senegalese isolates of Plasmodium falciparum. J Antimicrob Chemother 57: 1093-1099 [Abstract] [Full Text]  
  • Leon-Sicairos, N., Lopez-Soto, F., Reyes-Lopez, M., Godinez-Vargas, D., Ordaz-Pichardo, C., de la Garza, M. (2006). Amoebicidal Activity of Milk, Apo-lactoferrin, sIgA and Lysozyme.. Clin Med Res 4: 106-113 [Abstract] [Full Text]  
  • Avery, A. M., Goddard, H. J., Sumner, E. R., Avery, S. V. (2004). Iron Blocks the Accumulation and Activity of Tetracyclines in Bacteria. Antimicrob. Agents Chemother. 48: 1892-1894 [Abstract] [Full Text]  
  • Mahmoudi, N., Ciceron, L., Franetich, J.-F., Farhati, K., Silvie, O., Eling, W., Sauerwein, R., Danis, M., Mazier, D., Derouin, F. (2003). In Vitro Activities of 25 Quinolones and Fluoroquinolones against Liver and Blood Stage Plasmodium spp.. Antimicrob. Agents Chemother. 47: 2636-2639 [Abstract] [Full Text]  
  • Pradines, B., Rolain, J. M., Ramiandrasoa, F., Fusai, T., Mosnier, J., Rogier, C., Daries, W., Baret, E., Kunesch, G., Le Bras, J., Parzy, D. (2002). Iron chelators as antimalarial agents: in vitro activity of dicatecholate against Plasmodium falciparum. J Antimicrob Chemother 50: 177-187 [Abstract] [Full Text]  
  • Emerson, L. R., Nau, M. E., Martin, R. K., Kyle, D. E., Vahey, M., Wirth, D. F. (2002). Relationship between Chloroquine Toxicity and Iron Acquisition in Saccharomyces cerevisiae. Antimicrob. Agents Chemother. 46: 787-796 [Abstract] [Full Text]  
  • Pradines, B., Ramiandrasoa, F., Rolain, J. M., Rogier, C., Mosnier, J., Daries, W., Fusai, T., Kunesch, G., Le Bras, J., Parzy, D. (2002). In Vitro Potentiation of Antibiotic Activities by a Catecholate Iron Chelator against Chloroquine-Resistant Plasmodium falciparum. Antimicrob. Agents Chemother. 46: 225-228 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»