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Antimicrobial Agents and Chemotherapy, June 2001, p. 1788-1793, Vol. 45, No. 6
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.6.1788-1793.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Inhibition of Group A Streptococcus Infection by Carboxyfullerene

Nina Tsao,1 Tien-Yau Luh,2 Chen-Kung Chou,3 Jiunn-Jong Wu,4 Yee-Shin Lin,1 and Huan-Yao Lei1,*

Department of Microbiology and Immunology1 and Department of Medical Technology,4 College of Medicine, National Cheng Kung University, Tainan, and Department of Chemistry, National Taiwan University,2 and Department of Medical Research, Veterans General Hospital,3 Taipei, Taiwan

Received 24 October 2000/Returned for modification 29 December 2000/Accepted 2 March 2001

The effect of a water-soluble trimalonic acid derivative of fullerene, carboxyfullerene, against Streptococcus pyogenes infection was tested. Pretreatment with carboxyfullerene was able to protect mice from S. pyogenes infection in an air pouch model. S. pyogenes-induced death and skin injury were inhibited dose dependently by carboxyfullerene. Administration of carboxyfullerene via the peritoneum and air pouch at 3 h post-S. pyogenes infection was able to protect 33% of mice from death. Surveys of exudates of the air pouch of carboxyfullerene-treated mice revealed that survival of infiltrating neutrophils was prolonged and that the bacteria were eliminated as a result of enhanced bactericidal activity of the neutrophils. Furthermore, carboxyfullerene was able to directly inhibit in vitro growth of S. pyogenes. These data suggest that carboxyfullerene can be considered an antimicrobial agent for group A streptococcus infection.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China. Phone: 886-6-2353535, ext. 5643. Fax: 886-6-2097825. E-mail: hylei{at}mail.ncku.edu.tw.

Antimicrobial Agents and Chemotherapy, June 2001, p. 1788-1793, Vol. 45, No. 6
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.6.1788-1793.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Yoon, E. J., Jo, Y. W., Choi, S. H., Lee, T. H., Rhee, J. K., Yoo, M., Shim, M. J., Choi, E. C. (2005). In Vitro and In Vivo Activities of DA-7867, a New Oxazolidinone, against Aerobic Gram-Positive Bacteria. Antimicrob. Agents Chemother. 49: 2498-2500 [Abstract] [Full Text]  
  • Tsao, N., Luh, T.-Y., Chou, C.-K., Chang, T.-Y., Wu, J.-J., Liu, C.-C., Lei, H.-Y. (2002). In vitro action of carboxyfullerene. J Antimicrob Chemother 49: 641-649 [Abstract] [Full Text]  


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