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Antimicrobial Agents and Chemotherapy, June 2001, p. 1882-1885, Vol. 45, No. 6
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.6.1882-1885.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

In Vitro Activities of Terbinafine against Aspergillus Species in Comparison with Those of Itraconazole and Amphotericin B

Caroline B. Moore,¹ Caroline M. Walls,^1, and David W. Denning^2,3,4,*

Departments of Microbiology¹ and Medicine,² Hope Hospital, Salford, Department of Infectious Diseases and Tropical Medicine, North Manchester General Hospital,³ and University of Manchester,⁴ Manchester, United Kingdom

Received 11 September 2000/Returned for modification 4 January 2001/Accepted 5 March 2001

Compared with the in vitro activities of itraconazole (geometric mean MIC [GM], 0.56 µg/ml) and amphotericin B (GM, 0.66 µg/ml), the in vitro activity of terbinafine was inferior against Aspergillus fumigatus (GM, 19.03 µg/ml) (P < 0.05) and superior against A. flavus (GM, 0.10 µg/ml), A. terreus (GM, 0.16 µg/ml), and A. niger (GM, 0.19 µg/ml). Clinical correlation is required, as trailing endpoints are problematic.

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^* Corresponding author. Mailing address: Department of Infectious Diseases and Tropical Medicine, North Manchester General Hospital, Delaunays Rd., Manchester M8 6RB, United Kingdom. Phone: (44) 161 720 2734. Fax: (44) 161 720 2732. E-mail: ddenning{at}man.ac.uk.

Present address: Health & Safety Executive, Magdalen House, Stanley Precinct, Bootle, Merseyside, L20 3QZ, United Kingdom.

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Antimicrobial Agents and Chemotherapy, June 2001, p. 1882-1885, Vol. 45, No. 6
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.6.1882-1885.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

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