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Antimicrobial Agents and Chemotherapy, June 2001, p. 1886-1888, Vol. 45, No. 6
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.6.1886-1888.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

In Vitro Activities of DU-1102, a New Trioxaquine Derivative, against Plasmodium falciparum Isolates

Leonardo K. Basco,1 Odile Dechy-Cabaret,2 Mathieu Ndounga,1 Fleurette Solange Meche,1 Anne Robert,2 and Bernard Meunier2,*

Institut de Recherche pour le Développement-Laboratoire de Recherche sur le Paludisme, Organisation de Coordination pour la lutte contre les Endémies en Afrique Centrale (OCEAC), Yaoundé, Cameroon,1 and Laboratoire de Chimie de Coordination du CNRS, 31077 Toulouse Cedex 4, France2

Received 15 December 2000/Returned for modification 18 January 2001/Accepted 5 March 2001

The antimalarial trioxaquine derivative DU-1102, synthesized by covalent linkage between aminoquinoline and trioxane moieties, was highly active against Cameroonian isolates (mean 50% inhibitory concentration of 43 nmol/liter) of Plasmodium falciparum. There was no correlation between the responses to DU-1102 and chloroquine and only a low correlation between the responses to DU-1102 and pyrimethamine, suggesting an independent mode of action of the trioxaquine against the parasites.

* Corresponding author. Mailing address: Laboratoire de Chimie de Coordination du CNRS, 205 route de Narbonne, 31077 Toulouse Cedex 4, France. Phone: 33 5 61 33 31 46. Fax: 33 5 61 55 30 03. E-mail: bmeunier{at}lcc-toulouse.fr.

Antimicrobial Agents and Chemotherapy, June 2001, p. 1886-1888, Vol. 45, No. 6
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.6.1886-1888.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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