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Antimicrobial Agents and Chemotherapy, June 2001, p. 1892-1893, Vol. 45, No. 6
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.6.1892-1893.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Salmonella Excretion after Cessation of Tosufloxacin Therapy in Acute Nontyphoid Salmonella Enterocolitis

Kenji Ohnishi^* and Kyoko Kimura

Department of Infectious Diseases, Tokyo Metropolitan Bokutoh General Hospital, Tokyo, Japan

Received 26 October 2000/Returned for modification 12 January 2001/Accepted 1 March 2001

Symptomatic nontyphoid salmonella enterocolitis patients were treated with tosufloxacin (TFLX) at oral doses of 150 mg three times a day for 5 to 7 days, but bacterial relapse without symptoms occurred in 85% of the patients within 15 days after the cessation of therapy. Our study indicates that TFLX may not be an ideal drug against symptomatic salmonella enterocolitis from a bacteriological point of view.

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^* Corresponding author. Mailing address: Department of Infectious Diseases, Tokyo Metropolitan Bokutoh General Hospital, 4-23-15 Kohtohbashi, Sumida City, Tokyo 130-8575, Japan. Phone: 81 3 3633 6151. Fax: 81 3 3633 6173. E-mail: snow-crystal{at}msi.biglobe.ne.jp.

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Antimicrobial Agents and Chemotherapy, June 2001, p. 1892-1893, Vol. 45, No. 6
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.6.1892-1893.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.