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Antimicrobial Agents and Chemotherapy, June 2001, p. 1905-1907, Vol. 45, No. 6
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.6.1905-1907.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Azasordarins: Susceptibility of Fluconazole-Susceptible and Fluconazole-Resistant Clinical Isolates of Candida spp. to GW 471558

Manuel Cuenca-Estrella,* Emilia Mellado, Teresa M. Díaz-Guerra, Araceli Monzón, and Juan L. Rodríguez-Tudela

Servicio de Micología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, 28220 Majadahonda (Madrid), Spain

Received 19 January 2001/Returned for modification 22 February 2001/Accepted 12 March 2001

The in vitro activity of the azasordarin GW 471558 was compared with those of amphotericin B, flucytosine, itraconazole, and ketoconazole against 177 clinical isolates of Candida spp. GW 471558 showed potent activity against Candida albicans, Candida glabrata, and Candida tropicalis, even against isolates with decreased susceptibility to azoles. Candida krusei, Candida parapsilosis, Candida lusitaniae, and Candida guilliermondii are resistant to GW 471558 in vitro (MICs, >128 µg/ml).

* Corresponding author. Mailing address: Servicio de Micología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Ctra. Majadahonda-Pozuelo Km 2., 28220 Majadahonda (Madrid), Spain. Phone: 34-91-5097961. Fax: 34-91-5097966. E-mail: mcuenca-estrella{at}isciii.es.

Antimicrobial Agents and Chemotherapy, June 2001, p. 1905-1907, Vol. 45, No. 6
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.6.1905-1907.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.




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