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Antimicrobial Agents and Chemotherapy, June 2001, p. 1911-1914, Vol. 45, No. 6
0066-4804/01/$04.00+0 DOI: 10.1128/AAC.45.6.1911-1914.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.
Evaluation of Susceptibility Testing To Detect
Fluoroquinolone Resistance Mechanisms in Streptococcus
pneumoniae
David C.
Richardson,
Darrin
Bast,
Allison
McGeer, and
Donald E.
Low*
Toronto Medical Laboratories and Mount Sinai
Hospital Department of Microbiology, Mount Sinai Hospital, University
of Toronto, Toronto, Ontario, Canada
Received 23 October 2000/Returned for modification 23 February
2001/Accepted 15 March 2001
To determine if susceptibility testing of Streptococcus
pneumoniae could detect those isolates that had one of the
recognized mechanisms of fluoroquinolone resistance, 101 isolates were
selected; the levofloxacin MIC for 28 of these isolates was
4
µg/ml. Only isolates with both parC and
gyrA mutations or with no recognized resistance
mechanisms were reliably identified by using these results. Isolates
with only a parC mutation could not be detected reliably
using any susceptibility testing method.
*
Corresponding author. Mailing address: Dept. of
Microbiology, Mount Sinai Hospital, 600 University Ave., Rm. 1487, Toronto, Ontario M5G 1X5, Canada. Phone: (416) 586-4435. Fax: (416)
586-8746. E-mail: dlow{at}mtsinai.on.ca.
Antimicrobial Agents and Chemotherapy, June 2001, p. 1911-1914, Vol. 45, No. 6
0066-4804/01/$04.00+0 DOI: 10.1128/AAC.45.6.1911-1914.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.
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