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Antimicrobial Agents and Chemotherapy, June 2001, p. 1911-1914, Vol. 45, No. 6
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.6.1911-1914.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Evaluation of Susceptibility Testing To Detect Fluoroquinolone Resistance Mechanisms in Streptococcus pneumoniae

David C. Richardson, Darrin Bast, Allison McGeer, and Donald E. Low*

Toronto Medical Laboratories and Mount Sinai Hospital Department of Microbiology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada

Received 23 October 2000/Returned for modification 23 February 2001/Accepted 15 March 2001

To determine if susceptibility testing of Streptococcus pneumoniae could detect those isolates that had one of the recognized mechanisms of fluoroquinolone resistance, 101 isolates were selected; the levofloxacin MIC for 28 of these isolates was >= 4 µg/ml. Only isolates with both parC and gyrA mutations or with no recognized resistance mechanisms were reliably identified by using these results. Isolates with only a parC mutation could not be detected reliably using any susceptibility testing method.

* Corresponding author. Mailing address: Dept. of Microbiology, Mount Sinai Hospital, 600 University Ave., Rm. 1487, Toronto, Ontario M5G 1X5, Canada. Phone: (416) 586-4435. Fax: (416) 586-8746. E-mail: dlow{at}mtsinai.on.ca.

Antimicrobial Agents and Chemotherapy, June 2001, p. 1911-1914, Vol. 45, No. 6
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.6.1911-1914.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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