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Antimicrobial Agents and Chemotherapy, July 2001, p. 1952-1954, Vol. 45, No. 7
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.7.1952-1954.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

In Vitro Activities of Linezolid, Meropenem, and Quinupristin-Dalfopristin against Group C and G Streptococci, Including Vancomycin-Tolerant Isolates

Theoklis Zaoutis,1 Lynn Steele Moore,2 Kathleen Furness,2 and Joel D. Klein1,*

Division of Pediatric Infectious Diseases, Alfred I. duPont Hospital for Children, Wilmington,1 and Infectious Diseases Laboratory, Christiana Hospital, Christiana Care Health System, Newark,2 Delaware

Received 17 August 2000/Returned for modification 1 February 2001/Accepted 30 March 2001

The in vitro activities of meropenem, linezolid, quinupristin-dalfopristin, vancomycin, and penicillin against 130 clinical isolates of group C and G streptococci, including vancomycin-tolerant isolates, were evaluated. Meropenem, linezolid, quinupristin-dalfopristin, vancomycin, and penicillin MICs at which 90% of the isolates were inhibited were 0.06, 2.0, 0.25, 0.5, and <= 0.016 µg/ml, respectively. Meropenem, linezolid, quinupristin-dalfopristin, and penicillin were active against group C and G streptococci, including vancomycin-resistant strains.

* Corresponding author. Mailing address: Division of Pediatric Infectious Diseases, Alfred I. duPont Hospital for Children, P.O. Box 269, Wilmington, DE 19899. Phone: (302) 651-4421. Fax: (302) 651-4463. E-mail: jklein{at}nemours.org.

Antimicrobial Agents and Chemotherapy, July 2001, p. 1952-1954, Vol. 45, No. 7
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.7.1952-1954.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.




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