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Antimicrobial Agents and Chemotherapy, July 2001, p. 2126-2128, Vol. 45, No. 7
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.7.2126-2128.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Antimicrobial Activities of Gatifloxacin against Nosocomial Isolates of Stenotrophomonas maltophilia Measured by MIC and Time-Kill Studies

Michael L. Cohn and Ken B. Waites*

Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama

Received 18 September 2000/Returned for modification 5 February 2001/Accepted 9 April 2001

We determined in vitro activities of gatifloxacin and seven other drugs against 100 isolates of Stenotrophomonas maltophilia using the agar gradient diffusion (Etest) method. Percentages of susceptible isolates were as follows: trimethoprim-sulfamethoxazole, 90%; gatifloxacin, 71%; levofloxacin, 57%; ticarcillin-clavulanic acid, 54%; ceftazidime, 49%; ciprofloxacin, 29%; cefepime, 21%; and piperacillin-tazobactam, 20%. Time-kill studies of three isolates indicated that gatifloxacin was bactericidal at times as early as 3 h of incubation when tested at concentrations equivalent to twice the MIC (two isolates) and 4 times the MIC (one isolate).

* Corresponding author. Mailing address: Department of Pathology, WP 230, 619 South 19th St., University of Alabama at Birmingham, Birmingham, AL 35249. Phone: (205) 934-0578. Fax: (205) 975-4468. E-mail: waites{at}path.uab.edu.

Antimicrobial Agents and Chemotherapy, July 2001, p. 2126-2128, Vol. 45, No. 7
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.7.2126-2128.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.




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