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Antimicrobial Agents and Chemotherapy, July 2001, p. 2134-2135, Vol. 45, No. 7
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.7.2134-2135.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Clarithromycin Resistance and Eradication of Helicobacter pylori in Children

N. Kalach,1,2,3 P. H. Benhamou,1 F. Campeotto,1 M. Bergeret,2 C. Dupont,1 and J. Raymond2,*

Division of Gastroenterology, Department of Pediatrics,1 and Department of Microbiology,2 Hôpital Saint Vincent de Paul, 75674 Paris Cedex 14, and Department of Pediatrics, Hôpital Saint Antoine, Université Catholique de Lille, 59000 Lille,3 France

Received 28 November 2000/Returned for modification 23 January 2001/Accepted 13 April 2001

Outcome of Helicobacter pylori infection was analyzed in 61 children treated with a triple therapy including clarithromycin. Bacterial eradication was obtained in all children with clarithromycin-susceptible strains but not in children with clarithromycin-resistant ones (P = 0.0001). H. pylori antimicrobial susceptibility is mandatory before choosing a treatment, and clarithromycin should be avoided in case of resistance.

* Corresponding author. Mailing address: Department of Microbiology, Hôpital Saint Vincent de Paul, 82, Avenue Denfert Rochereau, 75674 Paris Cedex 14, France. Phone: (33) 1-40 48 81 11. Fax: (33) 1-40 48 83 18. E-mail: j.raymond{at}svp.ap-hop-paris.fr.

Antimicrobial Agents and Chemotherapy, July 2001, p. 2134-2135, Vol. 45, No. 7
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.7.2134-2135.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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