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Antimicrobial Agents and Chemotherapy, July 2001, p. 2136-2140, Vol. 45, No. 7
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.7.2136-2140.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Fluoroquinolone Resistance in Anaerobic Bacteria following Exposure to Levofloxacin, Trovafloxacin, and Sparfloxacin in an In Vitro Pharmacodynamic Model

Gigi H. Ross,1,2 David H. Wright,1,2 Laurie Baeker Hovde,2 Marnie L. Peterson,1,2 and John C. Rotschafer1,2,*

University of Minnesota, College of Pharmacy, Minneapolis, Minnesota, 55455,1 and Regions Hospital, Department of Clinical Pharmacy, St. Paul, Minnesota, 551012

Received 24 February 2000/Returned for modification 4 July 2000/Accepted 18 April 2001

This investigation explored pharmacodynamic characteristics of fluoroquinolones against Bacteroides thetaiotamicron and the potential for development of resistance. An in vitro model was used to generate kill curves with three fluoroquinolones at various area under the concentration-time curve (AUC)/MIC ratios. Concentration-independent killing was observed. Increases in MICs were noted following exposure to fluoroquinolones at AUC/MIC ratios of 6 to 14.

* Corresponding author. Mailing address: Department of Clinical Pharmacy, Regions Hospital, 640 Jackson St., St. Paul, MN 55101. Phone: (651) 221-3896. Fax: (651) 292-4031. E-mail: rotsc001{at}tc.umn.edu.

Antimicrobial Agents and Chemotherapy, July 2001, p. 2136-2140, Vol. 45, No. 7
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.7.2136-2140.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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