Macrolide-Resistant Streptococcus pneumoniae in Canada during 1998-1999: Prevalence of mef(A) and erm(B) and Susceptibilities to Ketolides

doi:10.1128/AAC.45.7.2147-2150.2001

This Article

	Full Text
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager
	Reprints and Permissions
	Copyright Information
	Books from ASM Press
	MicrobeWorld

Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Hoban, D. J.
	Articles by Zhanel, G. G.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Hoban, D. J.
	Articles by Zhanel, G. G.

Previous Article | Next Article

Antimicrobial Agents and Chemotherapy, July 2001, p. 2147-2150, Vol. 45, No. 7
0066-4804/01/$04.00+0 DOI: 10.1128/AAC.45.7.2147-2150.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Macrolide-Resistant Streptococcus pneumoniae in Canada during 1998-1999: Prevalence of mef(A) and erm(B) and Susceptibilities to Ketolides

Daryl J. Hoban,¹^,² Aleksandra K. Wierzbowski,¹ Kim Nichol,¹ and George G. Zhanel¹^,²^,³^,⁴^,^*

Department of Medical Microbiology, Faculty of Medicine¹ and Faculty of Pharmacy,³ University of Manitoba, and Departments of Medicine⁴ and Clinical Microbiology,² Health Sciences Centre, Winnipeg, Manitoba, Canada

Received 22 January 2001/Returned for modification 2 March 2001/Accepted 9 April 2001

In this study (1998-1999), we collected 215 macrolide-resistant Streptococcus pneumoniae isolates from an ongoing CanadianRespiratory Organism Surveillance Study involving 23 centers representingall regions of Canada. The prevalence of erythromycin-resistantS. pneumoniae was 8% (215 of 2,688). Of the 215 isolates, 48.8%(105 of 215) were PCR positive for mef(A) and 46.5% (100 of 215)were PCR positive for erm(B). The ketolides telithromycin andABT-773 demonstrated excellent activity against both mef(A) (MICfor 90% of strains [MIC₉₀], 0.06 and 0.03 µg/ml, respectively)and erm(B) (MIC₉₀, 0.06 and 0.03 µg/ml, respectively) strainsof S. pneumoniae.

^* Corresponding author. Mailing address: Department of Clinical Microbiology, Health Sciences Centre, MS673-820 Sherbrook Street,Winnipeg, Manitoba R3A 1R9, Canada. Phone: (204) 787-4902. Fax:(204) 787-4699. E-mail: ggzhanel{at}pcs.mb.ca.

This article has been cited by other articles:

Del Grosso, M., Northwood, J. G. E., Farrell, D. J., Pantosti, A. (2007). The Macrolide Resistance Genes erm(B) and mef(E) Are Carried by Tn2010 in Dual-Gene Streptococcus pneumoniae Isolates Belonging to Clonal Complex CC271. Antimicrob. Agents Chemother. 51: 4184-4186 [Abstract] [Full Text]
Wierzbowski, A. K., Nichol, K., Laing, N., Hisanaga, T., Nikulin, A., Karlowsky, J. A., Hoban, D. J., Zhanel, G. G. (2007). Macrolide resistance mechanisms among Streptococcus pneumoniae isolated over 6 years of Canadian Respiratory Organism Susceptibility Study (CROSS) (1998 2004). J Antimicrob Chemother 60: 733-740 [Abstract] [Full Text]
Hawkyard, C. V., Koerner, R. J. (2007). The use of erythromycin as a gastrointestinal prokinetic agent in adult critical care: benefits versus risks. J Antimicrob Chemother 59: 347-358 [Abstract] [Full Text]
Farrell, D. J., File, T. M., Jenkins, S. G. (2007). Prevalence and Antibacterial Susceptibility of mef(A)-Positive Macrolide-Resistant Streptococcus pneumoniae over 4 Years (2000 to 2004) of the PROTEKT US Study. J. Clin. Microbiol. 45: 290-293 [Abstract] [Full Text]
Del Grosso, M., Camilli, R., Iannelli, F., Pozzi, G., Pantosti, A. (2006). The mef(E)-Carrying Genetic Element (mega) of Streptococcus pneumoniae: Insertion Sites and Association with Other Genetic Elements.. Antimicrob. Agents Chemother. 50: 3361-3366 [Abstract] [Full Text]
Azoulay-Dupuis, E., Mohler, J., Bedos, J. P., Barau, C., Fantin, B. (2006). Efficacy of Cethromycin, a New Ketolide, against Streptococcus pneumoniae Susceptible or Resistant to Erythromycin in a Murine Pneumonia Model.. Antimicrob. Agents Chemother. 50: 3033-3038 [Abstract] [Full Text]
Sevillano, D., Alou, L., Aguilar, L., Echevarria, O., Gimenez, M.-J., Prieto, J. (2006). Azithromycin iv pharmacodynamic parameters predicting Streptococcus pneumoniae killing in epithelial lining fluid versus serum: an in vitro pharmacodynamic simulation. J Antimicrob Chemother 57: 1128-1133 [Abstract] [Full Text]
Wierzbowski, A. K., Boyd, D., Mulvey, M., Hoban, D. J., Zhanel, G. G. (2005). Expression of the mef(E) Gene Encoding the Macrolide Efflux Pump Protein Increases in Streptococcus pneumoniae with Increasing Resistance to Macrolides. Antimicrob. Agents Chemother. 49: 4635-4640 [Abstract] [Full Text]
Rantala, M., Huikko, S., Huovinen, P., Jalava, J., the Finnish Study Group for Antimicrobial Resistan, (2005). Prevalence and Molecular Genetics of Macrolide Resistance among Streptococcus pneumoniae Isolates Collected in Finland in 2002. Antimicrob. Agents Chemother. 49: 4180-4184 [Abstract] [Full Text]
Zhanel, G. G., Johanson, C., Laing, N., Hisanaga, T., Wierzbowski, A., Hoban, D. J. (2005). Pharmacodynamic Activity of Telithromycin at Simulated Clinically Achievable Free-Drug Concentrations in Serum and Epithelial Lining Fluid against Efflux (mefE)-Producing Macrolide- Resistant Streptococcus pneumoniae for Which Telithromycin MICs Vary. Antimicrob. Agents Chemother. 49: 1943-1948 [Abstract] [Full Text]
Kasbekar, N., Acharya, P. S. (2005). Telithromycin: The first ketolide for the treatment of respiratory infections. Am J Health Syst Pharm 62: 905-916 [Abstract] [Full Text]
Klaassen, C. H. W., Mouton, J. W. (2005). Molecular Detection of the Macrolide Efflux Gene: To Discriminate or Not To Discriminate between mef(A) and mef(E). Antimicrob. Agents Chemother. 49: 1271-1278 [Full Text]
Wierzbowski, A. K., Swedlo, D., Boyd, D., Mulvey, M., Nichol, K. A., Hoban, D. J., Zhanel, G. G. (2005). Molecular Epidemiology and Prevalence of Macrolide Efflux Genes mef(A) and mef(E) in Streptococcus pneumoniae Obtained in Canada from 1997 to 2002. Antimicrob. Agents Chemother. 49: 1257-1261 [Abstract] [Full Text]
Zhanel, G. G., Johanson, C., Hisanaga, T., Mendoza, C., Laing, N., Noreddin, A., Wierzbowski, A., Hoban, D. J. (2004). Pharmacodynamic activity of telithromycin against macrolide-susceptible and macrolide-resistant Streptococcus pneumoniae simulating clinically achievable free serum and epithelial lining fluid concentrations. J Antimicrob Chemother 54: 1072-1077 [Abstract] [Full Text]
Novotny, G. W., Jakobsen, L., Andersen, N. M., Poehlsgaard, J., Douthwaite, S. (2004). Ketolide Antimicrobial Activity Persists after Disruption of Interactions with Domain II of 23S rRNA. Antimicrob. Agents Chemother. 48: 3677-3683 [Abstract] [Full Text]
Kresken, M., Henrichfreise, B., Bagel, S., Brauers, J., Wiedemann, B. (2004). High Prevalence of the ermB Gene among Erythromycin-Resistant Streptococcus pneumoniae Isolates in Germany during the Winter of 2000-2001 and In Vitro Activity of Telithromycin. Antimicrob. Agents Chemother. 48: 3193-3195 [Abstract] [Full Text]
Daly, M. M., Doktor, S., Flamm, R., Shortridge, D. (2004). Characterization and Prevalence of MefA, MefE, and the Associated msr(D) Gene in Streptococcus pneumoniae Clinical Isolates. J. Clin. Microbiol. 42: 3570-3574 [Abstract] [Full Text]
Del Grosso, M., Scotto d'Abusco, A., Iannelli, F., Pozzi, G., Pantosti, A. (2004). Tn2009, a Tn916-Like Element Containing mef(E) in Streptococcus pneumoniae. Antimicrob. Agents Chemother. 48: 2037-2042 [Abstract] [Full Text]
Dandliker, P. J., Pratt, S. D., Nilius, A. M., Black-Schaefer, C., Ruan, X., Towne, D. L., Clark, R. F., Englund, E. E., Wagner, R., Weitzberg, M., Chovan, L. E., Hickman, R. K., Daly, M. M., Kakavas, S., Zhong, P., Cao, Z., David, C. A., Xuei, X., Lerner, C. G., Soni, N. B., Bui, M., Shen, L. L., Cai, Y., Merta, P. J., Saiki, A. Y. C., Beutel, B. A. (2003). Novel Antibacterial Class. Antimicrob. Agents Chemother. 47: 3831-3839 [Abstract] [Full Text]
Zhanel, G. G., DeCorby, M., Noreddin, A., Mendoza, C., Cumming, A., Nichol, K., Wierzbowski, A., Hoban, D. J. (2003). Pharmacodynamic activity of azithromycin against macrolide-susceptible and -resistant Streptococcus pneumoniae simulating clinically achievable free serum, epithelial lining fluid and middle ear fluid concentrations. J Antimicrob Chemother 52: 83-88 [Abstract] [Full Text]
Zhanel, G. G., Palatnick, L., Nichol, K. A., Bellyou, T., Low, D. E., Hoban, D. J. (2003). Antimicrobial Resistance in Respiratory Tract Streptococcus pneumoniae Isolates: Results of the Canadian Respiratory Organism Susceptibility Study, 1997 to 2002. Antimicrob. Agents Chemother. 47: 1867-1874 [Abstract] [Full Text]
Reinert, R. R., Lutticken, R., Bryskier, A., Al-Lahham, A. (2003). Macrolide-Resistant Streptococcus pneumoniae and Streptococcus pyogenes in the Pediatric Population in Germany during 2000-2001. Antimicrob. Agents Chemother. 47: 489-493 [Abstract] [Full Text]
Mason, E. O. Jr., Lamberth, L. B., Wald, E. R., Bradley, J. S., Barson, W. J., Kaplan, S. L. (2003). In Vitro Activities of Cethromycin (ABT-773), a New Ketolide, against Streptococcus pneumoniae Strains That Are Not Susceptible to Penicillin or Macrolides. Antimicrob. Agents Chemother. 47: 166-169 [Abstract] [Full Text]
Montanari, M. P., Mingoia, M., Cochetti, I., Varaldo, P. E. (2003). Phenotypes and Genotypes of Erythromycin-Resistant Pneumococci in Italy. J. Clin. Microbiol. 41: 428-431 [Abstract] [Full Text]
Noreddin, A. M., Roberts, D., Nichol, K., Wierzbowski, A., Hoban, D. J., Zhanel, G. G. (2002). Pharmacodynamic Modeling of Clarithromycin against Macrolide-Resistant [PCR-Positive mef(A) or erm(B)] Streptococcus pneumoniae Simulating Clinically Achievable Serum and Epithelial Lining Fluid Free-Drug Concentrations. Antimicrob. Agents Chemother. 46: 4029-4034 [Abstract] [Full Text]
Hamilton-Miller, J. M. T., Shah, S. (2002). Activity of ketolide ABT-773 (cethromycin) against erythromycin-resistant Streptococcus pneumoniae: correlation with extended MLSK phenotypes. J Antimicrob Chemother 50: 907-913 [Abstract] [Full Text]
Low, D. E., de Azavedo, J., Weiss, K., Mazzulli, T., Kuhn, M., Church, D., Forward, K., Zhanel, G., Simor, A., McGeer, A. (2002). Antimicrobial Resistance among Clinical Isolates of Streptococcus pneumoniae in Canada during 2000. Antimicrob. Agents Chemother. 46: 1295-1301 [Abstract] [Full Text]
Fuchs, P. C., Barry, A. L., Brown, S. D. (2002). In vitro activity of telithromycin against Streptococcus pneumoniae resistant to other antibiotics, including cefotaxime. J Antimicrob Chemother 49: 399-401 [Abstract] [Full Text]

Clin. Vaccine Immunol.	Clin. Microbiol. Rev.
J. Clin. Microbiol.	ALL ASM JOURNALS