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Antimicrobial Agents and Chemotherapy, July 2001, p. 2147-2150, Vol. 45, No. 7
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.7.2147-2150.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Macrolide-Resistant Streptococcus pneumoniae in Canada during 1998-1999: Prevalence of mef(A) and erm(B) and Susceptibilities to Ketolides

Daryl J. Hoban,1,2 Aleksandra K. Wierzbowski,1 Kim Nichol,1 and George G. Zhanel1,2,3,4,*

Department of Medical Microbiology, Faculty of Medicine1 and Faculty of Pharmacy,3 University of Manitoba, and Departments of Medicine4 and Clinical Microbiology,2 Health Sciences Centre, Winnipeg, Manitoba, Canada

Received 22 January 2001/Returned for modification 2 March 2001/Accepted 9 April 2001

In this study (1998-1999), we collected 215 macrolide-resistant Streptococcus pneumoniae isolates from an ongoing Canadian Respiratory Organism Surveillance Study involving 23 centers representing all regions of Canada. The prevalence of erythromycin-resistant S. pneumoniae was 8% (215 of 2,688). Of the 215 isolates, 48.8% (105 of 215) were PCR positive for mef(A) and 46.5% (100 of 215) were PCR positive for erm(B). The ketolides telithromycin and ABT-773 demonstrated excellent activity against both mef(A) (MIC for 90% of strains [MIC90], 0.06 and 0.03 µg/ml, respectively) and erm(B) (MIC90, 0.06 and 0.03 µg/ml, respectively) strains of S. pneumoniae.

* Corresponding author. Mailing address: Department of Clinical Microbiology, Health Sciences Centre, MS673-820 Sherbrook Street, Winnipeg, Manitoba R3A 1R9, Canada. Phone: (204) 787-4902. Fax: (204) 787-4699. E-mail: ggzhanel{at}pcs.mb.ca.

Antimicrobial Agents and Chemotherapy, July 2001, p. 2147-2150, Vol. 45, No. 7
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.7.2147-2150.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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