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Antimicrobial Agents and Chemotherapy, July 2001, p. 2151-2153, Vol. 45, No. 7
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.7.2151-2153.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

In Vitro Activities of Four Novel Triazoles against Scedosporium spp.

A. J. Carrillo1 and J. Guarro2,*

Department of Microbiology, Asesoría Científica y de Investigación Aplicada, 08037 Barcelona,1 and Unitat de Microbiologia, Facultat de Medicina, and Institut d'Estudis Avançats, Universitat Rovira i Virgili, 43201 Reus,2 Spain

Received 30 January 2001/Returned for modification 22 February 2001/Accepted 9 April 2001

In order to develop new approaches to the treatment of the severe and usually fatal infections caused by Scedosporium spp., the in vitro antifungal activities of four novel triazoles (posaconazole, ravuconazole, voriconazole, and UR-9825) and some current antifungals (amphotericin B, ketoconazole, itraconazole, and nystatin) were determined. The latter group was clearly ineffective against the two species tested. The four new antifungals showed activity against Scedosporium apiospermum, and UR-9825 and voriconazole were active against S. prolificans.

* Corresponding author. Mailing address: Unitat de Microbiologia, Facultat de Medicina, Universitat Rovira i Virgili, C/St. Llorenç, 21, 43201 Reus, Spain. Phone: (34) 977-759359. Fax: (34) 977-759322. E-mail: umb{at}fmcs.urv.es.

Antimicrobial Agents and Chemotherapy, July 2001, p. 2151-2153, Vol. 45, No. 7
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.7.2151-2153.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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