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Antimicrobial Agents and Chemotherapy, July 2001, p. 2163-2168, Vol. 45, No. 7
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.7.2163-2168.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Comparative In Vitro Activity of ABT-773, a Novel Antibacterial Ketolide

A. M. Nilius,* M. H. Bui, L. Almer, D. Hensey-Rudloff, J. Beyer, Z. Ma, Y. S. Or,dagger and R. K. Flamm

Infectious Diseases Research, Abbott Laboratories, Abbott Park, Illinois 60064-3537

Received 5 September 2000/Returned for modification 13 February 2001/Accepted 30 March 2001

The in vitro activities of ABT-773, erythromycin, clarithromycin, and azithromycin were compared. ABT-773 was the most active compound against macrolide-susceptible Streptococcus pneumoniae, Streptococcus pyogenes, Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Enterococcus spp. and multidrug-resistant Streptococcus pneumoniae. It also had good activity against gram-negative and atypical respiratory tract pathogens and Helicobacter pylori.

* Corresponding author. Mailing address: D47T, AP52, Abbott Laboratories, Abbott Park, IL 60064-3537. Phone: (847) 937-7706. Fax: (847) 935-0400. E-mail: angela.nilius{at}abbott.com.

dagger Present address: Enanta Pharmaceuticals, Cambridge, MA 02139.

Antimicrobial Agents and Chemotherapy, July 2001, p. 2163-2168, Vol. 45, No. 7
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.7.2163-2168.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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