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Antimicrobial Agents and Chemotherapy, July 2001, p. 2169-2172, Vol. 45, No. 7
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.7.2169-2172.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Activity of LY333328 in Experimental Meningitis Caused by a Streptococcus pneumoniae Strain Susceptible to Penicillin

Joachim Gerber,¹ Alexander Smirnov,¹ Andreas Wellmer,¹ Jasmin Ragheb,¹ Juliane Prange,¹ Eckhardt Schütz,² Klaus Wettich,³ Siegfried Kalich,³ and Roland Nau^1,*

Departments of Neurology¹ and Laboratory Medicine,² University of Göttingen, Göttingen, and Lilly Deutschland, Bad Homburg,³ Germany

Received 5 September 2000/Returned for modification 13 January 2001/Accepted 15 April 2001

In a rabbit model of Streptococcus pneumoniae meningitis single doses of 10 and 2.5 mg of the glycopeptide LY333328 per kg of body weight reduced bacterial titers in cerebrospinal fluid (CSF) almost as rapidly as ceftriaxone at 10 mg/kg/h (changes in log CFU, 0.29 ± 0.21 and 0.26 ± 0.22 versus 0.34 ± 0.15/ml/h). A dose of 1 mg/kg was bacteriostatic (change in log CFU, 0.01 ± 0.11/ml/h). In two animals receiving LY333328 at a dose of 40 mg/kg the bacterial titers were reduced by 0.54 and 0.51 log CFU/ml/h. The penetration of CSF by LY333328 was 1 to 5%. The concentrations of lipoteichoic and teichoic acids in CSF and neuronal damage were similar in ceftriaxone- and LY333328-treated animals.

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^* Corresponding author. Mailing address: Department of Neurology, University of Göttingen, Robert-Koch-Str. 40, D-37075 Göttingen, Germany. Phone: 49-551-398455 or -396684. Fax: 49-551-398405. E-mail: rnau{at}gwdg.de.

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Antimicrobial Agents and Chemotherapy, July 2001, p. 2169-2172, Vol. 45, No. 7
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.7.2169-2172.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

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