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Antimicrobial Agents and Chemotherapy, August 2001, p. 2368-2371, Vol. 45, No. 8
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.8.2368-2371.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Identification of a Plasmid Encoding SHV-12, TEM-1, and a Variant of IMP-2 Metallo-beta -Lactamase, IMP-8, from a Clinical Isolate of Klebsiella pneumoniae

Jing-Jou Yan,1 Wen-Chien Ko,2 and Jiunn-Jong Wu3,*

Departments of Pathology1 and Medicine,2 National Cheng Kung University Medical Center, and Department of Medical Technology,3 National Cheng Kung University Medical College, Tainan, Taiwan

Received 7 December 2000/Returned for modification 20 March 2001/Accepted 11 May 2001

A multidrug-resistant plasmid encoding TEM-1, SHV-12, and a variant of IMP-2 metallo-beta -lactamase, designated IMP-8, was identified from a clinical isolate of Klebsiella pneumoniae. There are four nucleotide differences between blaIMP-2 and blaIMP-8, resulting in two amino acid differences. blaIMP-8 was also found to be carried by an integron-borne gene cassette similar to the blaIMP-2 cassette.

* Corresponding author. Mailing address: Department of Medical Technology, National Cheng Kung University Medical College, 1 University Rd., Tainan, Taiwan 70101. Phone: 886-6-2353535, ext. 5775. Fax: 886-6-2363956. E-mail: jjwu{at}mail.ncku.edu.tw.

Antimicrobial Agents and Chemotherapy, August 2001, p. 2368-2371, Vol. 45, No. 8
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.8.2368-2371.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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