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Antimicrobial Agents and Chemotherapy, August 2001, p. 2375-2377, Vol. 45, No. 8
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.8.2375-2377.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Prevalence of Macrolide Resistance Genes in Clinical Isolates of the Streptococcus anginosus ("S. milleri") Group

Jan A. Jacobs,1,* Gilles J. van Baar,1 Nancy H. H. J. London,1 Jeroen H. T. Tjhie,1 Leo M. Schouls,2 and Ellen E. Stobberingh1

Department of Medical Microbiology, University Hospital Maastricht, Maastricht,1 and Research Laboratory for Infectious Diseases, National Institute of Public Health and the Environment, 3720 BA Bilthoven,2 The Netherlands

Received 19 October 2000/Returned for modification 28 November 2000/Accepted 17 May 2001

Twenty-two unrelated erythromycin-resistant anginosus group strains (3.2% resistance rate) were assessed for mechanisms of resistance. Streptococcus anginosus accounted for 16 of the 22 isolates. Fifteen isolates harbored the erm(B) gene. The erm(TR) and the mef(E) genes were carried by two isolates each. In three isolates, none of these resistance genes was detected by PCR.

* Corresponding author. Mailing address: Department of Medical Microbiology, University Hospital Maastricht, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands. Phone: 31-43-387 46 44. Fax: 31-43-387 66 43. E-mail: JJA{at}LMIB.azm.nl.

Antimicrobial Agents and Chemotherapy, August 2001, p. 2375-2377, Vol. 45, No. 8
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.8.2375-2377.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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