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Antimicrobial Agents and Chemotherapy, August 2001, p. 2383-2385, Vol. 45, No. 8
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.8.2383-2385.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Influence of Liposomal Amphotericin B on CD8 T-Cell Function

Marianne Kretschmar,1 Gernot Geginat,1 Thomas Bertsch,2 Simon Walter,1 Herbert Hof,1 and Thomas Nichterlein1,*

Institut für Medizinische Mikrobiologie und Hygiene,1 and Institut für Klinische Chemie,2 Fakultät für Klinische Medizin Mannheim der Universität Heidelberg, 68167 Mannheim, Germany

Received 3 November 2000/Returned for modification 16 December 2000/Accepted 8 May 2001

Liposomal amphotericin B was immunosuppressive on target cell lysis in vitro and on protection mediated by cytotoxic CD8 T cells in murine listeriosis. When dosages usually used for therapy in humans were compared, the immunosuppressive effect of 5 mg of liposomal amphotericin B/kg of body weight/day was similar to that of standard amphotericin B at 1 mg/kg/day, but a dosage of liposomal amphotericin B of 1 mg/kg/day was not suppressive in vivo.

* Corresponding author. Mailing address: Institut für Medizinische Mikrobiologie und Hygiene, Fakultät für Klinische Medizin Mannheim der Universität Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany. Phone: 621383-2695. Fax: 621383-3816. E-mail: thomas.nichterlein{at}imh.ma.uni-heidelberg.de.

Antimicrobial Agents and Chemotherapy, August 2001, p. 2383-2385, Vol. 45, No. 8
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.8.2383-2385.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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