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Antimicrobial Agents and Chemotherapy, August 2001, p. 2390-2392, Vol. 45, No. 8
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.8.2390-2392.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Activities of Gemifloxacin and Five Other Antimicrobial Agents against Listeria monocytogenes and Coryneform Bacteria Isolated from Clinical Samples

Luis Martínez-Martínez,* Providencia Joyanes, Ana I. Suárez, and Evelio J. Perea

Department of Microbiology, School of Medicine and University Hospital Virgen Macarena, Seville, Spain

Received 7 February 2000/Returned for modification 13 May 2000/Accepted 3 May 2001

The in vitro activities of gemifloxacin, ciprofloxacin, ampicillin, doxycycline, gentamicin, and vancomycin were evaluated against 15 Listeria monocytogenes strains and 205 coryneform bacteria isolated from clinical samples. The percentages of strains inhibited by gemifloxacin at 0.5 µg/ml were 100% (L. monocytogenes), 93.3% (Brevibacterium spp.), 90% (Corynebacterium minutissimum), 42.5% (Corynebacterium amycolatum), 20% (Corynebacterium striatum), 12.5% (Corynebacterium jeikeium), and 10% (Corynebacterium urealyticum). One hundred percent of the L. monocytogenes strains were inhibited by 0.25 µg of gemifloxacin per ml, whereas 0% of the strains were inhibited by 0.25 µg of ciprofloxacin per ml. Vancomycin at 2 µg/ml inhibited all strains. Doxycycline and gentamicin at 4 µg/ml inhibited 94 and 49% of the strains, respectively, while ampicillin at 0.5, 2, and 8 µg/ml inhibited 24, 61, and 66% of the strains, respectively. It is concluded that gemifloxacin shows good in vitro activity against L. monocytogenes and coryneform bacteria except C. jeikeium and C. urealyticum.

* Corresponding author. Mailing address: Department of Microbiology, School of Medicine, University of Seville, Apdo. 914, 41080 Seville, Spain. Phone: 34 95 5008287. Fax: 34 95 4377413. E-mail: lmartin{at}cica.es.

Antimicrobial Agents and Chemotherapy, August 2001, p. 2390-2392, Vol. 45, No. 8
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.8.2390-2392.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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