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Antimicrobial Agents and Chemotherapy, August 2001, p. 2397-2399, Vol. 45, No. 8
Department of Epidemiology, University of Michigan
School of Public Health, Ann Arbor, Michigan 48109
Received 2 April 2001/Returned for modification 24 April
2001/Accepted 21 May 2001
Artemisinin and its derivatives are endoperoxide-containing
antimalarial drugs that appear to form adducts in situ with the Plasmodium falciparum translationally controlled tumor
protein (TCTP) homolog. Immunoprecipitation with antibody to
recombinant TCTP suggests that adducts may form with both monomeric and
dimeric TCTP.
0066-4804/01/$04.00+0 DOI: 10.1128/AAC.45.8.2397-2399.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.
Immunoprecipitation of
[3H]Dihydroartemisinin Translationally Controlled Tumor
Protein (TCTP) Adducts from Plasmodium
falciparum-Infected Erythrocytes by Using Anti-TCTP
Antibodies
and
*
Corresponding author. Mailing address: Department of
Epidemiology, School of Public Health, University of Michigan, Ann
Arbor, MI 48109. Phone: (734) 647-2406. Fax: (734) 764-3192. E-mail: meshnick{at}umich.edu.
Present address: Department of Parasitology, Pramongkutklao College
of Medicine, Bangkok 10400, Thailand.
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