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Antimicrobial Agents and Chemotherapy, August 2001, p. 2397-2399, Vol. 45, No. 8
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.8.2397-2399.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Immunoprecipitation of [3H]Dihydroartemisinin Translationally Controlled Tumor Protein (TCTP) Adducts from Plasmodium falciparum-Infected Erythrocytes by Using Anti-TCTP Antibodies

Jamaree Bhisutthibhandagger and Steven R. Meshnick*

Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan 48109

Received 2 April 2001/Returned for modification 24 April 2001/Accepted 21 May 2001

Artemisinin and its derivatives are endoperoxide-containing antimalarial drugs that appear to form adducts in situ with the Plasmodium falciparum translationally controlled tumor protein (TCTP) homolog. Immunoprecipitation with antibody to recombinant TCTP suggests that adducts may form with both monomeric and dimeric TCTP.


* Corresponding author. Mailing address: Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109. Phone: (734) 647-2406. Fax: (734) 764-3192. E-mail: meshnick{at}umich.edu.

dagger Present address: Department of Parasitology, Pramongkutklao College of Medicine, Bangkok 10400, Thailand.


Antimicrobial Agents and Chemotherapy, August 2001, p. 2397-2399, Vol. 45, No. 8
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.8.2397-2399.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.



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