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Antimicrobial Agents and Chemotherapy, September 2001, p. 2524-2528, Vol. 45, No. 9
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.9.2524-2528.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

In Vitro Activities of 10 Antifungal Drugs against 508 Dermatophyte Strains

B. Fernández-Torres,1 A. J. Carrillo,2 E. Martín,3 A. Del Palacio,4 M. K. Moore,5 A. Valverde,3 M. Serrano,3 and J. Guarro1,*

Unitat de Microbiología, Facultat de Medicina and Institut d'Estudis Avançats, Universitat Rovira i Virgili, Reus,1 Department of Microbiology, Asesoría Científica y de Investigación Aplicada, Barcelona,2 Hospital de Valme, Sevilla,3 and Hospital 12 de Octubre, Madrid,4 Spain, and St. Thomas's Hospital, London, United Kingdom5

Received 19 December 2000/Returned for modification 16 February 2001/Accepted 18 June 2001

We have tested 508 strains belonging to 24 species of dermatophytes against 10 antifungal drugs following mainly the NCCLS (M38-P) standard for filamentous fungi. However, several important factors, such as the temperature (28 versus 35°C) and time of incubation (4 to 10 days versus 21 to 74 h), have been modified. The antifungals used were itraconazole, ketoconazole, miconazole, clotrimazole, voriconazole, terbinafine, amphotericin B, fluconazole, UR-9825, and G-1. In general, with the exception of fluconazole and G-1, all antifungals were shown to be highly effective.

* Corresponding author. Mailing address: Unitat de Microbiologia, Facultat de Medicina, Institut d'Estudis Avançats, Universitat Rovira i Virgili, Carrer Sant Llorenç, 21, 43201, Reus, Spain. Phone: 34-977-759359. Fax: 34-977-759322. E-mail: umb{at}astor.urv.es.

Antimicrobial Agents and Chemotherapy, September 2001, p. 2524-2528, Vol. 45, No. 9
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.9.2524-2528.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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