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Antimicrobial Agents and Chemotherapy, September 2001, p. 2623-2627, Vol. 45, No. 9
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.9.2623-2627.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Treatment of Visceral Leishmaniasis with Sterically Stabilized Liposomes Containing Camptothecin

Marie-Eve Proulx, André Désormeaux, Jean-François Marquis, Martin Olivier, and Michel G. Bergeron*

Centre de Recherche en Infectiologie, Université Laval, Québec, Québec, Canada

Received 15 November 2000/Returned for modification 6 December 2000/Accepted 21 May 2001

The efficacy of 20(S)-camptothecin (CPT), free and incorporated into sterically stabilized liposomes, has been investigated in vitro against Leishmania donovani promastigotes and in vivo in a murine model of visceral leishmaniasis. Incubation of L. donovani promastigotes with free or liposomal CPT inhibited the growth of parasites in a dose-dependent manner. Tissue distribution studies revealed that the intraperitoneal administration of liposomal CPT was efficient for the delivery of high drug levels to the liver and spleen. Treatment of infected mice with intraperitoneal injections of free and liposomal CPT significantly reduced the parasite loads in the livers by 43 and 55%, respectively, compared with the loads for untreated controls. However, both treatments caused normochromic anemia and neutropenia.

* Corresponding author. Mailing address: Centre de Recherche en Infectiologie, Centre Hospitalier Universitaire de Québec, Pavillon CHUL, 2705 Blvd. Laurier, Ste-Foy, QC, Canada G1V 4G2. Phone: (418) 654-2705. Fax: (418) 654-2715. E-mail: Michel.G.Bergeron{at}crchul.ulaval.ca.

Antimicrobial Agents and Chemotherapy, September 2001, p. 2623-2627, Vol. 45, No. 9
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.9.2623-2627.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Marquis, J.-F., Hardy, I., Olivier, M. (2005). Topoisomerase I Amino Acid Substitutions, Gly185Arg and Asp325Glu, Confer Camptothecin Resistance in Leishmania donovani. Antimicrob. Agents Chemother. 49: 1441-1446 [Abstract] [Full Text]  


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