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Antimicrobial Agents and Chemotherapy, September 2001, p. 2628-2630, Vol. 45, No. 9
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.9.2628-2630.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Risk Factors for Emergence of Resistance to Broad-Spectrum Cephalosporins among Enterobacter spp.

Keith S. Kaye,1,* Sara Cosgrove,1 Anthony Harris,2 George M. Eliopoulos,1 and Yehuda Carmeli1

Division of Infectious Diseases and Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts,1 and the Division of Healthcare Outcomes, Department of Epidemiology and Preventive Medicine, University of Maryland, Baltimore, Maryland2

Received 25 January 2001/Returned for modification 19 March 2001/Accepted 25 May 2001

Among 477 patients with susceptible Enterobacter spp., 49 subsequently harbored third-generation cephalosporin-resistant Enterobacter spp. Broad-spectrum cephalosporins were independent risk factors for resistance (relative risk [OR] = 2.3, P = 0.01); quinolone therapy was protective (OR = 0.4, P = 0.03). There were trends toward decreased risk for resistance among patients receiving broad-spectrum cephalosporins and either aminoglycosides or imipenem. Of the patients receiving broad-spectrum cephalosporins, 19% developed resistance.

* Corresponding author. Mailing address: Duke University Medical Center, Box 3152, Durham, NC 27710. Phone: (919) 668-1720. Fax: (919) 684-3137. E-mail: kaye0001{at}mc.duke.edu.

Antimicrobial Agents and Chemotherapy, September 2001, p. 2628-2630, Vol. 45, No. 9
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.9.2628-2630.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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