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Antimicrobial Agents and Chemotherapy, September 2001, p. 2631-2634, Vol. 45, No. 9
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.9.2631-2634.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Interspecies Recombination Contributes Minimally to Fluoroquinolone Resistance in Streptococcus pneumoniae

Darrin J. Bast,1,2,* Joyce C. S. de Azavedo,1,2 Tiffany Y. Tam,1 Laurie Kilburn,1 Carla Duncan,1 Lionel A. Mandell,3 Ross J. Davidson,4 and Donald E. Low1,2

Department of Microbiology, Toronto Medical Laboratories and Mount Sinai Hospital,1 and Department of Laboratory Medicine and Pathobiology, University of Toronto,2 Toronto, Division of Infectious Diseases, McMaster University, and Henderson Site, Hamilton Health Sciences Corporation, Hamilton,3 and Department of Microbiology, Queen Elizabeth II Health Sciences Centre, Dalhousie University, Halifax,4 Canada

Received 12 February 2001/Returned for modification 16 April 2001/Accepted 31 May 2001

Analysis of 71 ciprofloxacin-resistant (MIC >=  4 µg/ml) Streptococcus pneumoniae clinical isolates revealed only 1 for which the quinolone resistance-determining regions of the parC, parE, and gyrB genes were genetically related to those of viridans group streptococci. Our findings support the occurrence of interspecies recombination of type II topoisomerase genes; however, its contribution to the emergence of quinolone resistance among pneumococci appears to have been minimal.

* Corresponding author. Mailing address: Department of Microbiology, Mount Sinai Hospital, 600 University Ave., Room 1483, Toronto, Ontario M5G 1X5, Canada. Phone: (416) 586-4800, ext. 3207. Fax: (416) 586-8746. E-mail: dbast{at}mtsinai.on.ca.

Antimicrobial Agents and Chemotherapy, September 2001, p. 2631-2634, Vol. 45, No. 9
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.9.2631-2634.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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