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Antimicrobial Agents and Chemotherapy, September 2001, p. 2643-2647, Vol. 45, No. 9
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.9.2643-2647.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Stability and Compatibility of Ceftazidime Administered by Continuous Infusion to Intensive Care Patients

Hélène Servais* and Paul M. Tulkens

Unité de Pharmacologie Cellulaire et Moléculaire, Université catholique de Louvain, Brussels, Belgium

Received 23 October 2000/Returned for modification 11 March 2001/Accepted 5 June 2001

The stability and compatibility of ceftazidime have been examined in the context of its potential use in concentrated solutions for continuous infusion in patients suffering from severe nosocomial pneumonia and receiving other intravenous medications by the same route. Ceftazidime stability in 4 to 12% solutions was found satisfactory (<10% degradation) for 24 h if kept at a temperature of 25°C (77°F) maximum. Studies mimicking the simultaneous administration of ceftazidime and other drugs as done in clinics showed physical incompatibilities with vancomycin, nicardipine, midazolam, and propofol and a chemical incompatibility with N-acetylcystein. Concentrated solutions (50 mg/ml) of erythromycin or clarithromycin caused the appearance of a precipitate, whereas gentamicin, tobramycin, amikacin, isepamicin, fluconazole, ketamine, sufentanil, valproic acid, furosemide, uradipil, and a standard amino acid solution were physically and chemically compatible.

* Corresponding author. Mailing address: Unité de Pharmacologie Cellulaire et Moléculaire, Université catholique de Louvain, UCL 73.70 avenue E. Mounier 73, B-1200 Brussels, Belgium. Phone: 32-2-764.73.56. Fax: 32-2-764.73.73. E-mail: Helene.Servais{at}facm.ucl.ac.be.

Antimicrobial Agents and Chemotherapy, September 2001, p. 2643-2647, Vol. 45, No. 9
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.9.2643-2647.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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