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Antimicrobial Agents and Chemotherapy, September 2001, p. 2651-2654, Vol. 45, No. 9
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.9.2651-2654.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Multidrug-Resistant Strains of Neisseria gonorrhoeae in Greece

Angeliki Mavroidi,1 Leonidas S. Tzouvelekis,2 Kyriakos P. Kyriakis,1 Helen Avgerinou,3 Maria Daniilidou,4 and Eva Tzelepi1,*

National Reference Center for Neisseria gonorrhoeae, Department of Bacteriology, Hellenic Pasteur Institute,1 Laboratory of Antimicrobial Agents, Department of Microbiology, Athens University Medical School,2 and Microbiology Laboratory, "Andreas Sygros" Hospital for Skin and Venereal Diseases,3 Athens, and Microbiology Laboratory, Venereal Hospital of Thessaloniki, Thessaloniki,4 Greece

Received 16 March 2001/Returned for modification 5 June 2001/Accepted 27 June 2001

Eighty-seven out of 575 gonococci isolated in Greece from 1991 to 1998 belonged to serovar Bropyst and exhibited resistance to penicillin, tetracycline, erythromycin, and chloramphenicol. Conventional and molecular typing showed three clusters, A, B, and C, that were associated with networks of high- frequency transmitters (cluster A with homosexuals and clusters B and C with refugees from Eastern Europe). Study of one isolate revealed mutations in the penA, mtrR, and porB genes that may explain the multidrug-resistant phenotype.

* Corresponding author. Mailing address: Department of Bacteriology, Hellenic Pasteur Institute, 127 Vass. Sofias Ave., 11521-Athens, Greece. Phone: 30 (1) 6478810. Fax: 30 (1) 6423498. E-mail: tzelepi{at}mail.pasteur.gr.

Antimicrobial Agents and Chemotherapy, September 2001, p. 2651-2654, Vol. 45, No. 9
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.9.2651-2654.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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