Integrons and Gene Cassettes in the Enterobacteriaceae

doi:10.1128/AAC.45.9.2658-2661.2001

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Antimicrobial Agents and Chemotherapy, September 2001, p. 2658-2661, Vol. 45, No. 9
0066-4804/01/$04.00+0 DOI: 10.1128/AAC.45.9.2658-2661.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Integrons and Gene Cassettes in the Enterobacteriaceae

Peter A. White,^* Christopher J. McIver, and William D. Rawlinson

Virology Division, Department of Microbiology, SEALS, Prince of Wales Hospital, Randwick, Sydney NSW 2031, and School of Pathology, Faculty of Medicine and School of Microbiology and Immunology, Faculty of Science, The University of New South Wales, Sydney 2052, Australia

Received 5 September 2000/Returned for modification 14 February 2001/Accepted 25 June 2001

Integrons were detected in 59 of 120 (49%) urinary isolates of Enterobacteriaceae by PCR using degenerate primers targetedto conserved regions of class 1, 2, and 3 integrase genes. PCRsequencing analysis of the cassette arrays revealed a predominanceof cassettes that confer resistance to the aminoglycosides andtrimethoprim.

^* Corresponding author. Mailing address: Virology Division, Department of Microbiology, SEALS, Prince of Wales Hospital, Randwick,NSW 2031, Australia. Phone: 61 2 9382 9096. Fax: 61 2 9398 4275.E-mail: whitepa{at}sesahs.nsw.gov.au.

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