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Antimicrobial Agents and Chemotherapy, January 2002, p. 132-134, Vol. 46, No. 1
0066-4804/01/$04.00+0     DOI: 10.1128/AAC.46.1.132-134.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Efficacy of Short-Course Ceftriaxone Therapy for Borrelia burgdorferi Infection in C3H Mice

Division of Infectious Diseases, Departments of Medicine,¹ New York College of Osteopathic Medicine Microbiology and Immunodiagnostic Laboratory of the New York Institute of Technology, Old Westbury, New York 11578,² Pharmacology, New York Medical College, Valhalla, New York 10595³

Received 14 May 2001/ Returned for modification 13 August 2001/ Accepted 14 October 2001

Ceftriaxone is highly effective clinically in patients with Lyme disease. We studied a representative invasive human isolate of Borrelia burgdorferi for which the MBC of ceftriaxone was 0.050 µg/ml. A once-per-day dosage regimen of ceftriaxone (50 mg/kg/dose) administered intramuscularly for 5 days was 100% effective in sterilizing tissue samples of C3H mice infected with this strain of B. burgdorferi, regardless of whether the mice were being treated concomitantly with a corticosteroid. Administration of the same five doses of ceftriaxone at 6-h intervals over just 24 h was also 100% effective. These experiments suggest that shorter courses of antibiotics than those currently recommended should be considered for study in patients with early uncomplicated Lyme disease.

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