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Antimicrobial Agents and Chemotherapy, January 2002, p. 184-187, Vol. 46, No. 1
0066-4804/01/$04.00+0     DOI: 10.1128/AAC.46.1.184-187.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Efficacies of BMS 284756 against Penicillin-Sensitive, Penicillin-Resistant, and Quinolone-Resistant Pneumococci in Experimental Meningitis

Philippe Cottagnoud,1* Fernando Acosta,2 Marianne Cottagnoud,2 Marc Pfister,3 and Martin G. Täuber4

Department of Internal Medicine, Inselspital,1 Department of Internal Medicine, Zieglerspital,2 Institute for Infectious Diseases, University of Bern, Bern, Switzerland,4 Department of Laboratory Medicine and Biopharmaceutical Sciences, University of California, San Francisco, California3

Received 22 February 2001/ Returned for modification 24 August 2001/ Accepted 15 October 2001

BMS 284756 penetrated well into inflamed meninges (44% ± 11%) and produced good bactericidal activity (-0.82 ± 0.22 {Delta}log10 CFU/ml · h) in the treatment of experimental meningitis in rabbits due to a penicillin-sensitive strain. BMS 284756 monotherapy had a greater potency than the standard regimen of ceftriaxone and vancomycin (-0.49 ± 0.08 {Delta}log10 CFU/ml · h) against a penicillin-resistant strain (MIC, 4 mg/liter). Even against a penicillin- and quinolone-resistant strain, BMS 284756 showed good bactericidal activity (-0.52 ± 0.12 {Delta}log10 CFU/ml · h). The antibacterial activity of BMS 284756 was confirmed by time-killing assays over 8 h in vitro.

* Corresponding author. Mailing address: Department of Internal Medicine, Inselspital, Bern, Switzerland. Phone: 41 316 322 111. Fax: 41 316 323 847. E-mail: pcottagn{at}insel.ch.

Antimicrobial Agents and Chemotherapy, January 2002, p. 184-187, Vol. 46, No. 1
0066-4804/01/$04.00+0     DOI: 10.1128/AAC.46.1.184-187.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Cottagnoud, P., Pfister, M., Acosta, F., Cottagnoud, M., Flatz, L., Kuhn, F., Muller, H.-P., Stucki, A. (2004). Daptomycin Is Highly Efficacious against Penicillin-Resistant and Penicillin- and Quinolone-Resistant Pneumococci in Experimental Meningitis. Antimicrob. Agents Chemother. 48: 3928-3933 [Abstract] [Full Text]  
  • Entenza, J. M., Vouillamoz, J., Glauser, M. P., Moreillon, P. (2004). Efficacy of Garenoxacin in Treatment of Experimental Endocarditis Due to Staphylococcus aureus or Viridans Group Streptococci. Antimicrob. Agents Chemother. 48: 86-92 [Abstract] [Full Text]  
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  • Pfister, M., Zhang, L., Hammarlund-Udenaes, M., Sheiner, L. B., Gerber, C. M., Tauber, M. G., Cottagnoud, P. (2003). Modeling of Transfer Kinetics at the Serum-Cerebrospinal Fluid Barrier in Rabbits with Experimental Meningitis: Application to Grepafloxacin. Antimicrob. Agents Chemother. 47: 138-143 [Abstract] [Full Text]  


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