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Antimicrobial Agents and Chemotherapy, January 2002, p. 188-190, Vol. 46, No. 1
0066-4804/01/$04.00+0     DOI: 10.1128/AAC.46.1.188-190.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Gentamicin Increases the Efficacy of Vancomycin against Penicillin-Resistant Pneumococci in the Rabbit Meningitis Model

Philippe Cottagnoud,1* Cynthia M. Gerber,2 Marianne Cottagnoud,2 and Martin G. Täuber3

Department of Internal Medicine, Inselspital, 3010 Bern,1 Department of Internal Medicine, Zieglerspital, 3007 Bern,2 Institute for Infectious Diseases, University of Bern, 3012 Bern, Switzerland3

Received 15 December 2000/ Returned for modification 30 May 2001/ Accepted 14 October 2001

In experimental meningitis a single dose of gentamicin (10 mg/kg of body weight) led to gentamicin levels in around cerebrospinal fluid (CSF) of 4 mg/liter for 4 h, decreasing slowly to 2 mg/liter 4 h later. The CSF penetration of gentamicin ranged around 27%, calculated by comparison of areas under the curve (AUC in serum/AUC in CSF). Gentamicin monotherapy (-1.24 log10 CFU/ml) was inferior to vancomycin monotherapy (-2.54 log10 CFU/ml) over 8 h against penicillin-resistant pneumococci. However, the combination of vancomycin with gentamicin was significantly superior (-4.48 log10 CFU/ml) compared to either monotherapy alone. The synergistic activity of vancomycin combined with gentamicin was also demonstrated in vitro in time-kill assays.

* Corresponding author. Mailing address: Department of Internal Medicine, Inselspital, 3010 Bern, Switzerland. Phone: 41316322111. Fax: 41316323847. E-mail: pcottagn{at}insel.ch.

Antimicrobial Agents and Chemotherapy, January 2002, p. 188-190, Vol. 46, No. 1
0066-4804/01/$04.00+0     DOI: 10.1128/AAC.46.1.188-190.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Cottagnoud, P., Johnson, M., Cottagnoud, M., Piddock, L. (2005). Preincubation of Pneumococci with {beta}-Lactams Alone or Combined with Levofloxacin Prevents Quinolone-Induced Resistance without Increasing Intracellular Levels of Levofloxacin. Antimicrob. Agents Chemother. 49: 3517-3519 [Abstract] [Full Text]  
  • Kuhn, F., Cottagnoud, M., Acosta, F., Flatz, L., Entenza, J., Cottagnoud, P. (2003). Cefotaxime Acts Synergistically with Levofloxacin in Experimental Meningitis Due to Penicillin-Resistant Pneumococci and Prevents Selection of Levofloxacin-Resistant Mutants In Vitro. Antimicrob. Agents Chemother. 47: 2487-2491 [Abstract] [Full Text]  
  • Cottagnoud, P., Cottagnoud, M., Tauber, M. G. (2003). Vancomycin Acts Synergistically with Gentamicin against Penicillin-Resistant Pneumococci by Increasing the Intracellular Penetration of Gentamicin. Antimicrob. Agents Chemother. 47: 144-147 [Abstract] [Full Text]  


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