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Antimicrobial Agents and Chemotherapy, January 2002, p. 216-219, Vol. 46, No. 1
0066-4804/01/$04.00+0     DOI: 10.1128/AAC.46.1.216-219.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Postneurosurgical Meningitis Due to Proteus penneri with Selection of a Ceftriaxone-Resistant Isolate: Analysis of Chromosomal Class A ß-Lactamase HugA and its LysR-Type Regulatory Protein HugR

Nadia Liassine,1* Stéphanie Madec,2 Béatrice Ninet,1 Catherine Metral,1 Martine Fouchereau-Peron,3 Roger Labia,2 and Raymond Auckenthaler1

Central Laboratory of Bacteriology, University Hospital, Geneva, Switzerland,1 Centre National de la Recherche Scientifique, Unité FRE 2125, Quimper,2 Centre de Biologie Marine, Unité FRE 2125, Concarneau, France3

Received 30 January 2001/ Returned for modification 29 May 2001/ Accepted 29 September 2001

We report on a case of a postneurosurgical meningitis due to ceftriaxone-susceptible Proteus penneri, with selection of a ceftriaxone-resistant isolate following treatment with ceftriaxone. The isolates presented identical patterns by pulsed-field gel electrophoresis and produced a single ß-lactamase named HugA with an isoelectric point of 6.7. The ceftriaxone-resistant isolate hyperproduced the ß-lactamase (increase in the level of production, about 90-fold). The sequences of the hugA ß-lactamase gene and its regulator, hugR, were identical in both P. penneri strains and had 85.96% homology with those of Proteus vulgaris. The HugA ß-lactamase belongs to molecular class A, and the transcriptional regulator HugR belongs to the LysR family.

* Corresponding author. Present address: Laboratoire Bioanalytique-Riotton, 53 avenue Blanc, 1211 Geneva 2, Switzerland. Phone: (41) (22) 716 20 04. Fax: (41) (22) 716 20 07. E-mail: nliassine{at}unilabs.ch.

Antimicrobial Agents and Chemotherapy, January 2002, p. 216-219, Vol. 46, No. 1
0066-4804/01/$04.00+0     DOI: 10.1128/AAC.46.1.216-219.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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