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Antimicrobial Agents and Chemotherapy, January 2002, p. 225-228, Vol. 46, No. 1
0066-4804/01/$04.00+0     DOI: 10.1128/AAC.46.1.225-228.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

In Vitro Potentiation of Antibiotic Activities by a Catecholate Iron Chelator against Chloroquine-Resistant Plasmodium falciparum

Unité de Parasitologie, Institut de Médecine Tropicale du Service de Santé des Armées, Le Pharo, 13007 Marseille,¹ Laboratoire de Chimie Bioorganique et Bioinorganique, CNRS URA 1384, Institut de Chimie Moléculaire d’Orsay, 91405 Orsay,² Unité des Rickettsies, CNRS-UPRES A 6020, Faculté de Médecine, Université de la Méditerranée, 13385 Marseille,³ Centre National de Chimiosensibilité du Paludisme, Laboratoire de Parasitologie, Hôpital Bichat-Claude Bernard, 75018 Paris, France⁴

Received 2 August 2001/ Returned for modification 25 September 2001/ Accepted 15 October 2001

FR160, a catechol iron chelator, and tetracyclines or norfloxacin exert in vitro additive or synergistic activity against a chloroquine-resistant Plasmodium falciparum clone. FR160 shows antagonistic effects in association with macrolides, ofloxacin, and rifampin.

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