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Antimicrobial Agents and Chemotherapy, January 2002, p. 225-228, Vol. 46, No. 1
0066-4804/01/$04.00+0     DOI: 10.1128/AAC.46.1.225-228.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

In Vitro Potentiation of Antibiotic Activities by a Catecholate Iron Chelator against Chloroquine-Resistant Plasmodium falciparum

Bruno Pradines,1* Florence Ramiandrasoa,2 Jean Marc Rolain,1,3 Christophe Rogier,1 Joel Mosnier,1 William Daries,1 Thierry Fusai,1 Gerhard Kunesch,2 Jacques Le Bras,4 and Daniel Parzy1

Unité de Parasitologie, Institut de Médecine Tropicale du Service de Santé des Armées, Le Pharo, 13007 Marseille,1 Laboratoire de Chimie Bioorganique et Bioinorganique, CNRS URA 1384, Institut de Chimie Moléculaire d’Orsay, 91405 Orsay,2 Unité des Rickettsies, CNRS-UPRES A 6020, Faculté de Médecine, Université de la Méditerranée, 13385 Marseille,3 Centre National de Chimiosensibilité du Paludisme, Laboratoire de Parasitologie, Hôpital Bichat-Claude Bernard, 75018 Paris, France4

Received 2 August 2001/ Returned for modification 25 September 2001/ Accepted 15 October 2001

FR160, a catechol iron chelator, and tetracyclines or norfloxacin exert in vitro additive or synergistic activity against a chloroquine-resistant Plasmodium falciparum clone. FR160 shows antagonistic effects in association with macrolides, ofloxacin, and rifampin.

* Corresponding author. Mailing address: IMTSSA, Unité de Parasitologie, Bd Charles Livon, Parc le Pharo, BP 46, 13998 Marseille Armées, France. Phone: 33 4 91 15 01 10. Fax: 33 4 91 15 01 64. E-mail: bruno.pradines{at}free.fr.

Antimicrobial Agents and Chemotherapy, January 2002, p. 225-228, Vol. 46, No. 1
0066-4804/01/$04.00+0     DOI: 10.1128/AAC.46.1.225-228.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Pradines, B., Tall, A., Ramiandrasoa, F., Spiegel, A., Sokhna, C., Fusai, T., Mosnier, J., Daries, W., Trape, J. F., Kunesch, G., Parzy, D., Rogier, C. (2006). In vitro activity of iron-binding compounds against Senegalese isolates of Plasmodium falciparum. J Antimicrob Chemother 57: 1093-1099 [Abstract] [Full Text]  
  • Pradines, B., Rolain, J. M., Ramiandrasoa, F., Fusai, T., Mosnier, J., Rogier, C., Daries, W., Baret, E., Kunesch, G., Le Bras, J., Parzy, D. (2002). Iron chelators as antimalarial agents: in vitro activity of dicatecholate against Plasmodium falciparum. J Antimicrob Chemother 50: 177-187 [Abstract] [Full Text]  


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