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Antimicrobial Agents and Chemotherapy, January 2002, p. 234-238, Vol. 46, No. 1
0066-4804/01/$04.00+0     DOI: 10.1128/AAC.46.1.234-238.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Antimicrobial Activities of BMS-284756 Compared with Those of Fluoroquinolones and ß-Lactams against Gram-Positive Clinical Isolates

Matteo Bassetti,1* Louise M. Dembry,1,2 Patricia A. Farrel,2 Deborah A. Callan,2 and Vincent T. Andriole1

Yale University School of Medicine,1 Yale-New Haven Hospital New Haven, Connecticut2

Received 27 April 2001/ Returned for modification 30 July 2001/ Accepted 5 October 2001

The in vitro antibacterial activity of BMS-284756 was compared to those of ciprofloxacin, gatifloxacin, moxifloxacin, ceftriaxone, imipenem, piperacillin-tazobactam, and amoxicillin-clavulanic acid against 492 gram-positive clinical isolates. BMS-284756 was the most-active agent against Streptococcus pneumoniae, Streptococcus viridans, beta-hemolytic streptococci, methicillin-sensitive and -resistant Staphylococcus aureus, methicillin-sensitive and -resistant coagulase-negative staphylococci, and enterococci.

* Corresponding author. Mailing address: Clinica Malattie Infettive, Universitá di Genova, Ospedale San Martino, Largo R. Benzi, 10, 16132 Genova, Italy. Phone: 39 010 5552668. Fax: 39 010 3537680. E-mail: mattba{at}tin.it.

Antimicrobial Agents and Chemotherapy, January 2002, p. 234-238, Vol. 46, No. 1
0066-4804/01/$04.00+0     DOI: 10.1128/AAC.46.1.234-238.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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