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Antimicrobial Agents and Chemotherapy, January 2002, p. 242-244, Vol. 46, No. 1
0066-4804/01/$04.00+0     DOI: 10.1128/AAC.46.1.242-244.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Single-Dose Pharmacokinetics and Penetration of BMS 284756 into an Inflammatory Exudate

R. Wise, T. Gee, G. Marshall, and J. M. Andrews*

Department of Medical Microbiology, City Hospital NHS Trust, Birmingham, United Kingdom

Received 2 July 2001/ Returned for modification 16 September 2001/ Accepted 10 October 2001

The pharmacokinetics of a single dose of BMS 284756 were determined following oral administration of a 600-mg dose to eight healthy male volunteers. Concentrations of the drug were measured in plasma and a cantharidine-induced inflammatory exudate by a microbiological assay. The mean peak concentration in plasma of 10.4 µg/ml (standard deviation [SD], 1.3 µg/ml) was attained at a mean time of 1.2 h (SD, 0.5 h) after the dose. The penetration into the inflammatory exudate was 82% (SD, 15.7%). A mean peak concentration of 7.2 µg/ml (SD, 2.4 µg/ml) was attained in the inflammatory exudate at 5.3 h (SD, 1.5 h). The elimination half-lives from plasma and inflammatory fluid were 9.8 h (SD, 1.1 h) and 8.5 h (SD, 1.9 h), respectively. The areas under the concentration-time curves for plasma and inflammatory fluid were 96.7 µg · h/ml (SD, 10.3 µg · h/ml) and 77.9 µg · h/ml (SD, 19.2 µg · h/ml), respectively.

* Corresponding author. Mailing address: Department of Medical Microbiology, City Hospital NHS Trust, Dudley Rd., Birmingham B18 7QH, United Kingdom. Phone: 0121 507 4261 or 0121 507 4262. Fax: 0121 551 7763. E-mail: jenny.andrews{at}cityhospbham.wmids.nhs.uk.

Antimicrobial Agents and Chemotherapy, January 2002, p. 242-244, Vol. 46, No. 1
0066-4804/01/$04.00+0     DOI: 10.1128/AAC.46.1.242-244.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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