This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Arikan, S.
Right arrow Articles by Rex, J. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Arikan, S.
Right arrow Articles by Rex, J. H.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, January 2002, p. 245-247, Vol. 46, No. 1
0066-4804/01/$04.00+0     DOI: 10.1128/AAC.46.1.245-247.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

In Vitro Synergy of Caspofungin and Amphotericin B against Aspergillus and Fusarium spp.

Sevtap Arikan,* Mario Lozano-Chiu, Victor Paetznick, and John H. Rex

Division of Infectious Diseases, Department of Internal Medicine, Center for the Study of Emerging and Reemerging Pathogens, University of Texas Medical School, Houston, Texas 77030

Received 18 June 2001/ Returned for modification 18 September 2001/ Accepted 16 October 2001

We investigated the in vitro interaction of caspofungin and amphotericin B for clinical isolates of Aspergillus and Fusarium. Synergy tests were performed using the checkerboard method and following the NCCLS M38-P guidelines in Antibiotic Medium 3 broth supplemented to 2% glucose. Antagonism was not observed for any of the isolates tested. Caspofungin and amphotericin B were synergistic or synergistic to additive for at least half of the isolates.

* Corresponding author. Present address: Mycology Laboratory, Department of Microbiology and Clinical Microbiology, Hacettepe University Medical School, 06100 Ankara, Turkey. Phone: 90 312 3051562. Fax: 90 312 3115250. E-mail: sarikan{at}metu.edu.tr.

Antimicrobial Agents and Chemotherapy, January 2002, p. 245-247, Vol. 46, No. 1
0066-4804/01/$04.00+0     DOI: 10.1128/AAC.46.1.245-247.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • ZUPKO, I., RETHY, B., HOHMANN, J., MOLNAR, J., OCSOVSZKI, I., FALKAY, G. (2009). Antitumor Activity of Alkaloids Derived from Amaryllidaceae Species. In Vivo 23: 41-48 [Abstract] [Full Text]  
  • Chowdhry, R., Marshall, W. L. (2008). Analytical Reviews: Antifungal Therapies in the Intensive Care Unit. J Intensive Care Med 23: 151-158 [Abstract]  
  • Cuenca-Estrella, M., Alastruey-Izquierdo, A., Alcazar-Fuoli, L., Bernal-Martinez, L., Gomez-Lopez, A., Buitrago, M. J., Mellado, E., Rodriguez-Tudela, J. L. (2008). In Vitro Activities of 35 Double Combinations of Antifungal Agents against Scedosporium apiospermum and Scedosporium prolificans. Antimicrob. Agents Chemother. 52: 1136-1139 [Abstract] [Full Text]  
  • Meletiadis, J., Stergiopoulou, T., O'Shaughnessy, E. M., Peter, J., Walsh, T. J. (2007). Concentration-Dependent Synergy and Antagonism within a Triple Antifungal Drug Combination against Aspergillus Species: Analysis by a New Response Surface Model. Antimicrob. Agents Chemother. 51: 2053-2064 [Abstract] [Full Text]  
  • Azor, M., Gene, J., Cano, J., Guarro, J. (2007). Universal In Vitro Antifungal Resistance of Genetic Clades of the Fusarium solani Species Complex. Antimicrob. Agents Chemother. 51: 1500-1503 [Abstract] [Full Text]  
  • Khan, Z. U., Ahmad, S., Mokaddas, E., Said, T., Nair, M. P., Halim, M. A., Nampoory, M. R., McGinnis, M. R. (2007). Cerebral aspergillosis diagnosed by detection of Aspergillus flavus-specific DNA, galactomannan and (1->3)-{beta}-D-glucan in clinical specimens. J Med Microbiol 56: 129-132 [Abstract] [Full Text]  
  • O'Shaughnessy, E. M., Meletiadis, J., Stergiopoulou, T., P. Demchok, J., Walsh, T. J. (2006). Antifungal interactions within the triple combination of amphotericin B, caspofungin and voriconazole against Aspergillus species. J Antimicrob Chemother 58: 1168-1176 [Abstract] [Full Text]  
  • Spellberg, B., Schwartz, J., Fu, Y., Avanesian, V., Adler-Moore, J., Edwards, J. E. Jr, Ibrahim, A. S. (2006). Comparison of antifungal treatments for murine fusariosis. J Antimicrob Chemother 58: 973-979 [Abstract] [Full Text]  
  • Cuenca-Estrella, M., Gomez-Lopez, A., Buitrago, M. J., Mellado, E., Garcia-Effron, G., Rodriguez-Tudela, J. L. (2006). In Vitro Activities of 10 Combinations of Antifungal Agents against the Multiresistant Pathogen Scopulariopsis brevicaulis.. Antimicrob. Agents Chemother. 50: 2248-2250 [Abstract] [Full Text]  
  • van Vianen, W., de Marie, S., ten Kate, M. T., Mathot, R. A. A., Bakker-Woudenberg, I. A. J. M. (2006). Caspofungin: antifungal activity in vitro, pharmacokinetics, and effects on fungal load and animal survival in neutropenic rats with invasive pulmonary aspergillosis. J Antimicrob Chemother 57: 732-740 [Abstract] [Full Text]  
  • Heyn, K., Tredup, A., Salvenmoser, S., Muller, F.-M. C. (2005). Effect of Voriconazole Combined with Micafungin against Candida, Aspergillus, and Scedosporium spp. and Fusarium solani. Antimicrob. Agents Chemother. 49: 5157-5159 [Abstract] [Full Text]  
  • Yustes, C., Guarro, J. (2005). In Vitro Synergistic Interaction between Amphotericin B and Micafungin against Scedosporium spp.. Antimicrob. Agents Chemother. 49: 3498-3500 [Abstract] [Full Text]  
  • Philip, A., Odabasi, Z., Rodriguez, J., Paetznick, V. L., Chen, E., Rex, J. H., Ostrosky-Zeichner, L. (2005). In Vitro Synergy Testing of Anidulafungin with Itraconazole, Voriconazole, and Amphotericin B against Aspergillus spp. and Fusarium spp.. Antimicrob. Agents Chemother. 49: 3572-3574 [Abstract] [Full Text]  
  • Makowsky, M. J, Warkentin, D. I, Savoie, M L. (2005). Caspofungin and amphotericin B for disseminated Fusarium verticillioides in leukemia. The Annals of Pharmacotherapy 39: 1365-1366 [Full Text]  
  • Elzi, L., Laifer, G., Bremerich, J., Vosbeck, J., Mayr, M. (2005). Invasive apergillosis with myocardial involvement after kidney transplantation. Nephrol Dial Transplant 20: 631-634 [Full Text]  
  • Cuenca-Estrella, M., Gomez-Lopez, A., Garcia-Effron, G., Alcazar-Fuoli, L., Mellado, E., Buitrago, M. J., Rodriguez-Tudela, J. L. (2005). Combined Activity In Vitro of Caspofungin, Amphotericin B, and Azole Agents against Itraconazole-Resistant Clinical Isolates of Aspergillus fumigatus. Antimicrob. Agents Chemother. 49: 1232-1235 [Abstract] [Full Text]  
  • Serena, C., Pastor, F. J., Gilgado, F., Mayayo, E., Guarro, J. (2005). Efficacy of Micafungin in Combination with Other Drugs in a Murine Model of Disseminated Trichosporonosis. Antimicrob. Agents Chemother. 49: 497-502 [Abstract] [Full Text]  
  • Ibrahim, A. S., Bowman, J. C., Avanessian, V., Brown, K., Spellberg, B., Edwards, J. E. Jr., Douglas, C. M. (2005). Caspofungin Inhibits Rhizopus oryzae 1,3-{beta}-D-Glucan Synthase, Lowers Burden in Brain Measured by Quantitative PCR, and Improves Survival at a Low but Not a High Dose during Murine Disseminated Zygomycosis. Antimicrob. Agents Chemother. 49: 721-727 [Abstract] [Full Text]  
  • Singh, N., Paterson, D. L. (2005). Aspergillus Infections in Transplant Recipients. Clin. Microbiol. Rev. 18: 44-69 [Abstract] [Full Text]  
  • Mukherjee, P. K., Sheehan, D. J., Hitchcock, C. A., Ghannoum, M. A. (2005). Combination Treatment of Invasive Fungal Infections. Clin. Microbiol. Rev. 18: 163-194 [Abstract] [Full Text]  
  • Martino, R., DuPont, B., Huckle, H., Chopra, R. (2004). No Signs of New Toxicity When Amphotericin B Lipid Complex (ABLC, ABELCET) and Caspofungin Are Used in Combination in the Treatment of FUO.. ASH ANNUAL MEETING ABSTRACTS 104: 5077-5077 [Abstract]  
  • Cuenca-Estrella, M. (2004). Combinations of antifungal agents in therapy-what value are they?. J Antimicrob Chemother 54: 854-869 [Abstract] [Full Text]  
  • Markovich, S., Yekutiel, A., Shalit, I., Shadkchan, Y., Osherov, N. (2004). Genomic Approach to Identification of Mutations Affecting Caspofungin Susceptibility in Saccharomyces cerevisiae. Antimicrob. Agents Chemother. 48: 3871-3876 [Abstract] [Full Text]  
  • Barchiesi, F., Spreghini, E., Baldassarri, I., Marigliano, A., Arzeni, D., Giannini, D., Scalise, G. (2004). Sequential Therapy with Caspofungin and Fluconazole for Candida albicans Infection. Antimicrob. Agents Chemother. 48: 4056-4058 [Abstract] [Full Text]  
  • Steinbach, W. J., Perfect, J. R., Schell, W. A., Walsh, T. J., Benjamin, D. K. Jr. (2004). In Vitro Analyses, Animal Models, and 60 Clinical Cases of Invasive Aspergillus terreus Infection. Antimicrob. Agents Chemother. 48: 3217-3225 [Full Text]  
  • Yekutiel, A., Shalit, I., Shadkchan, Y., Osherov, N. (2004). In Vitro Activity of Caspofungin Combined with Sulfamethoxazole against Clinical Isolates of Aspergillus spp.. Antimicrob. Agents Chemother. 48: 3279-3283 [Abstract] [Full Text]  
  • Barchiesi, F., Spreghini, E., Maracci, M., Fothergill, A. W., Baldassarri, I., Rinaldi, M. G., Scalise, G. (2004). In Vitro Activities of Voriconazole in Combination with Three Other Antifungal Agents against Candida glabrata. Antimicrob. Agents Chemother. 48: 3317-3322 [Abstract] [Full Text]  
  • Odds, F. C., Motyl, M., Andrade, R., Bille, J., Canton, E., Cuenca-Estrella, M., Davidson, A., Durussel, C., Ellis, D., Foraker, E., Fothergill, A. W., Ghannoum, M. A., Giacobbe, R. A., Gobernado, M., Handke, R., Laverdiere, M., Lee-Yang, W., Merz, W. G., Ostrosky-Zeichner, L., Peman, J., Perea, S., Perfect, J. R., Pfaller, M. A., Proia, L., Rex, J. H., Rinaldi, M. G., Rodriguez-Tudela, J.-L., Schell, W. A., Shields, C., Sutton, D. A., Verweij, P. E., Warnock, D. W. (2004). Interlaboratory Comparison of Results of Susceptibility Testing with Caspofungin against Candida and Aspergillus Species. J. Clin. Microbiol. 42: 3475-3482 [Abstract] [Full Text]  
  • Ortoneda, M., Capilla, J., Pastor, F. J., Pujol, I., Yustes, C., Serena, C., Guarro, J. (2004). In Vitro Interactions of Approved and Novel Drugs against Paecilomyces spp.. Antimicrob. Agents Chemother. 48: 2727-2729 [Abstract] [Full Text]  
  • Shadkchan, Y., Shemesh, E., Mirelman, D., Miron, T., Rabinkov, A., Wilchek, M., Osherov, N. (2004). Efficacy of allicin, the reactive molecule of garlic, in inhibiting Aspergillus spp. in vitro, and in a murine model of disseminated aspergillosis. J Antimicrob Chemother 53: 832-836 [Abstract] [Full Text]  
  • Johnson, M. D., MacDougall, C., Ostrosky-Zeichner, L., Perfect, J. R., Rex, J. H. (2004). Combination Antifungal Therapy. Antimicrob. Agents Chemother. 48: 693-715 [Full Text]  
  • Dannaoui, E., Lortholary, O., Dromer, F. (2004). In Vitro Evaluation of Double and Triple Combinations of Antifungal Drugs against Aspergillus fumigatus and Aspergillus terreus. Antimicrob. Agents Chemother. 48: 970-978 [Abstract] [Full Text]  
  • Kowacs, P A, Monteiro de Almeida, S, Pinheiro, R L, Fameli, H, Piovesan, E J, Correia, A, Werneck, L C (2004). Central nervous system Aspergillus fumigatus infection after near drowning. J. Clin. Pathol. 57: 202-204 [Abstract] [Full Text]  
  • Imhof, A., Balajee, S. A., Marr, K. A. (2003). New Methods To Assess Susceptibilities of Aspergillus Isolates to Caspofungin. J. Clin. Microbiol. 41: 5683-5688 [Abstract] [Full Text]  
  • Nichols, W. G. (2003). Management of Infectious Complications in the Hematopoietic Stem Cell Transplant Recipient. J Intensive Care Med 18: 295-312 [Abstract]  
  • Arikan, S., Yurdakul, P., Hascelik, G. (2003). Comparison of Two Methods and Three End Points in Determination of In Vitro Activity of Micafungin against Aspergillus spp.. Antimicrob. Agents Chemother. 47: 2640-2643 [Abstract] [Full Text]  
  • Diekema, D. J., Messer, S. A., Hollis, R. J., Jones, R. N., Pfaller, M. A. (2003). Activities of Caspofungin, Itraconazole, Posaconazole, Ravuconazole, Voriconazole, and Amphotericin B against 448 Recent Clinical Isolates of Filamentous Fungi. J. Clin. Microbiol. 41: 3623-3626 [Abstract] [Full Text]  
  • Shalit, I., Shadkchan, Y., Samra, Z., Osherov, N. (2003). In Vitro Synergy of Caspofungin and Itraconazole against Aspergillus spp.: MIC versus Minimal Effective Concentration End Points. Antimicrob. Agents Chemother. 47: 1416-1418 [Abstract] [Full Text]  
  • Chan, J. (2003). Comment: caspofungin acetate for treatment of invasive fungal infections. The Annals of Pharmacotherapy 37: 595-595 [Full Text]  
  • Pfaller, M. A., Diekema, D. J., Messer, S. A., Hollis, R. J., Jones, R. N. (2003). In Vitro Activities of Caspofungin Compared with Those of Fluconazole and Itraconazole against 3,959 Clinical Isolates of Candida spp., Including 157 Fluconazole-Resistant Isolates. Antimicrob. Agents Chemother. 47: 1068-1071 [Abstract] [Full Text]  
  • Letscher-Bru, V., Herbrecht, R. (2003). Caspofungin: the first representative of a new antifungal class. J Antimicrob Chemother 51: 513-521 [Abstract] [Full Text]  
  • Bachmann, S. P., VandeWalle, K., Ramage, G., Patterson, T. F., Wickes, B. L., Graybill, J. R., Lopez-Ribot, J. L. (2002). In Vitro Activity of Caspofungin against Candida albicans Biofilms. Antimicrob. Agents Chemother. 46: 3591-3596 [Abstract] [Full Text]  
  • Paphitou, N. I., Ostrosky-Zeichner, L., Paetznick, V. L., Rodriguez, J. R., Chen, E., Rex, J. H. (2002). In Vitro Activities of Investigational Triazoles against Fusarium Species: Effects of Inoculum Size and Incubation Time on Broth Microdilution Susceptibility Test Results. Antimicrob. Agents Chemother. 46: 3298-3300 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»