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Antimicrobial Agents and Chemotherapy, January 2002, p. 259-261, Vol. 46, No. 1
0066-4804/01/$04.00+0     DOI: 10.1128/AAC.46.1.259-261.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Combination Therapy with Indolylquinoline Derivative and Sodium Antimony Gluconate Cures Established Visceral Leishmaniasis in Hamsters

Chiranjib Pal,1,{dagger} Mousumi Raha,2 Anirban Basu,1,{ddagger} Keshab Chandra Roy,1 Anasuya Gupta,3 Monidipa Ghosh,1 Niranjan Prasad Sahu,2 Sukdeb Banerjee,2 Nirup Bikash Mandal,2 and Santu Bandyopadhyay1*

Immunology Division,1 Steroid and Terpenoid Chemistry Division, Indian Institute of Chemical Biology, Jadavpur, Kolkata-700 032,2 Department of Zoology, Calcutta University, Kolkata-700 019, India3

Received 27 March 2001/ Returned for modification 5 June 2001/ Accepted 28 September 2001

2-(2''-Dichloroacetamidobenzyl)-3-(3'-indolylquinoline), designated indolylquinoline derivative A, reduced the splenic and the liver parasite burdens by >93.0% in Leishmania donovani-infected hamsters, whereas sodium antimony gluconate (SAG) reduced the burdens approximately 80.0%. Complete clearance of parasitemia from the livers and spleens was noticed when infected animals received indolylquinoline derivative A plus SAG, suggesting that indolylquinoline derivative A has potential as a new agent for sole or conjunctive therapy for leishmaniasis.

* Corresponding author. Mailing address: Division of Immunology, Indian Institute of Chemical Biology, 4, Raja S.C. Mullick Rd., Jadavpur, Kolkata-700 032, India. Phone: 91-33-473-3491. Fax: 91-33-473-5197/0284. E-mail: santu2{at}iicb.res.in and santu{at}iicb.res.in.

{dagger} Present address: Department of Zoology, B.K.C. College, Kolkata-700 035, India.

{ddagger} Present address: Department of Neuroscience and Anatomy, Pennsylvania State College of Medicine, Hershey, Pa.

Antimicrobial Agents and Chemotherapy, January 2002, p. 259-261, Vol. 46, No. 1
0066-4804/01/$04.00+0     DOI: 10.1128/AAC.46.1.259-261.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.





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