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Antimicrobial Agents and Chemotherapy, January 2002, p. 55-61, Vol. 46, No. 1
0066-4804/01/$04.00+0     DOI: 10.1128/AAC.46.1.55-61.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Novel Synthetic Polyamines Are Effective in the Treatment of Experimental Microsporidiosis, an Opportunistic AIDS-Associated Infection

Cyrus J. Bacchi,1* Louis M. Weiss,2,3 Schenella Lane,1 Benjamin Frydman,4 Aldonia Valasinas,4 Venodhar Reddy,4 Jerry S. Sun,4 Laurence J. Marton,4 Imitiaz A. Khan,5 Magali Moretto,5 Nigel Yarlett,1 and Murray Wittner3

Haskins Laboratories and Departments of Biology and Chemistry, Pace University, New York, New York,1 Departments of Medicine,2 Pathology Albert Einstein College of Medicine, Bronx, New York,3 SLIL Biomedical Corporation, Madison, Wisconsin,4 Department of Microbiology and Immunology, Louisiana State University Medical Center, New Orleans, Louisiana5

Received 18 June 2001/ Returned for modification 14 August 2001/ Accepted 25 September 2001

Microsporidia are eukaryotic obligate intracellular protists that are emerging pathogens in immunocompromised hosts, such as patients with AIDS or patients who have undergone organ transplantation. We have demonstrated in vitro and in vivo that synthetic polyamine analogs are effective antimicrosporidial agents with a broad therapeutic window. CD8-knockout mice or nude mice infected with the microsporidian Encephalitozoon cuniculi were cured when they were treated with four different novel polyamine analogs at doses ranging from 1.25 to 5 mg/kg of body weight/day for a total of 10 days. Cured animals demonstrated no evidence of parasitemia by either PCR or histologic staining of tissues 30 days after untreated control animals died.

* Corresponding author. Mailing address: Haskins Laboratories, Pace University, 41 Park Row, New York, NY 10038-1598. Phone: (212) 346-1246. Fax: (212) 346-1586. E-mail: cbacchi{at}pace.edu.

Antimicrobial Agents and Chemotherapy, January 2002, p. 55-61, Vol. 46, No. 1
0066-4804/01/$04.00+0     DOI: 10.1128/AAC.46.1.55-61.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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