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Antimicrobial Agents and Chemotherapy, October 2002, p. 3249-3252, Vol. 46, No. 10
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.10.3249-3252.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

DNA Sequence Analysis of DNA Gyrase and DNA Topoisomerase IV Quinolone Resistance-Determining Regions of Salmonella enterica Serovar Typhi and Serovar Paratyphi A

Kenji Hirose,1 Ai Hashimoto,1 Kazumichi Tamura,1 Yoshiaki Kawamura,2 Takayuki Ezaki,2 Hiroko Sagara,3 and Haruo Watanabe1*

Department of Bacteriology, National Institute of Infectious Diseases, 1-23-1, Toyama, Shinjuku-ku, Tokyo, 162-8640,1 Department of Microbiology, Gifu University, School of Medicine, 40 Tsukasa-machi, Gifu, 500-8750,2 Department of Infectious Diseases, Yokohama City Hospital, 56 Okazawa-cho, Hodogaya, Yokohama City, Kanagawa, 240-8555, Japan3

Received 7 February 2002/ Returned for modification 17 May 2002/ Accepted 20 June 2002

The mutations that are responsible for fluoroquinolone resistance in the gyrA, gyrB, parC, and parE genes of Salmonella enterica serovar Typhi and serovar Paratyphi A were investigated. The sequences of the quinolone resistance-determining region of the gyrA gene in clinical isolates which showed decreased susceptibilities to fluoroquinolones had a single mutation at either the Ser-83 or the Asp-87 codon, and no mutations were found in the gyrB, parC, and parE genes.

* Corresponding author. Mailing address: Department of Bacteriology, National Institute of Infectious Diseases, 1-23-1, Toyama, Shinjuku-ku, Tokyo, 162-8640, Japan. Phone: 81-3-5285-1111, ext. 2201. Fax: 81-3-5285-1171. E-mail: haruwata{at}nih.go.jp.

Antimicrobial Agents and Chemotherapy, October 2002, p. 3249-3252, Vol. 46, No. 10
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.10.3249-3252.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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