This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Hirose, K. Articles by Watanabe, H. Search for Related Content PubMed PubMed Citation Articles by Hirose, K. Articles by Watanabe, H.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, October 2002, p. 3249-3252, Vol. 46, No. 10
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.10.3249-3252.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

DNA Sequence Analysis of DNA Gyrase and DNA Topoisomerase IV Quinolone Resistance-Determining Regions of Salmonella enterica Serovar Typhi and Serovar Paratyphi A

Department of Bacteriology, National Institute of Infectious Diseases, 1-23-1, Toyama, Shinjuku-ku, Tokyo, 162-8640,¹ Department of Microbiology, Gifu University, School of Medicine, 40 Tsukasa-machi, Gifu, 500-8750,² Department of Infectious Diseases, Yokohama City Hospital, 56 Okazawa-cho, Hodogaya, Yokohama City, Kanagawa, 240-8555, Japan³

Received 7 February 2002/ Returned for modification 17 May 2002/ Accepted 20 June 2002

The mutations that are responsible for fluoroquinolone resistance in the gyrA, gyrB, parC, and parE genes of Salmonella enterica serovar Typhi and serovar Paratyphi A were investigated. The sequences of the quinolone resistance-determining region of the gyrA gene in clinical isolates which showed decreased susceptibilities to fluoroquinolones had a single mutation at either the Ser-83 or the Asp-87 codon, and no mutations were found in the gyrB, parC, and parE genes.

This article has been cited by other articles:

• Chau, T. T., Campbell, J. I., Galindo, C. M., Van Minh Hoang, N., Diep, T. S., Nga, T. T. T., Van Vinh Chau, N., Tuan, P. Q., Page, A. L., Ochiai, R. L., Schultsz, C., Wain, J., Bhutta, Z. A., Parry, C. M., Bhattacharya, S. K., Dutta, S., Agtini, M., Dong, B., Honghui, Y., Anh, D. D., Canh, D. G., Naheed, A., Albert, M. J., Phetsouvanh, R., Newton, P. N., Basnyat, B., Arjyal, A., La, T. T. P., Rang, N. N., Phuong, L. T., Van Be Bay, P., von Seidlein, L., Dougan, G., Clemens, J. D., Vinh, H., Hien, T. T., Chinh, N. T., Acosta, C. J., Farrar, J., Dolecek, C. (2007). Antimicrobial Drug Resistance of Salmonella enterica Serovar Typhi in Asia and Molecular Mechanism of Reduced Susceptibility to the Fluoroquinolones. Antimicrob. Agents Chemother. 51: 4315-4323 [Abstract] [Full Text]  
• Le, T. A. H., Fabre, L., Roumagnac, P., Grimont, P. A. D., Scavizzi, M. R., Weill, F.-X. (2007). Clonal Expansion and Microevolution of Quinolone-Resistant Salmonella enterica Serotype Typhi in Vietnam from 1996 to 2004. J. Clin. Microbiol. 45: 3485-3492 [Abstract] [Full Text]  
• Solnik-Isaac, H., Weinberger, M., Tabak, M., Ben-David, A., Shachar, D., Yaron, S. (2007). Quinolone Resistance of Salmonella enterica Serovar Virchow Isolates from Humans and Poultry in Israel: Evidence for Clonal Expansion. J. Clin. Microbiol. 45: 2575-2579 [Abstract] [Full Text]  
• WEILL, F.-X., TRAN, H. H., ROUMAGNAC, P., FABRE, L., MINH, N. B., STAVNES, T. L., LASSEN, J., BJUNE, G., GRIMONT, P. A.D., GUERIN, P. J. (2007). CLONAL RECONQUEST OF ANTIBIOTIC-SUSCEPTIBLE SALMONELLA ENTERICA SEROTYPE TYPHI IN SON LA PROVINCE, VIETNAM. Am J Trop Med Hyg 76: 1174-1181 [Abstract] [Full Text]  
• Chen, S., Cui, S., McDermott, P. F., Zhao, S., White, D. G., Paulsen, I., Meng, J. (2007). Contribution of Target Gene Mutations and Efflux to Decreased Susceptibility of Salmonella enterica Serovar Typhimurium to Fluoroquinolones and Other Antimicrobials. Antimicrob. Agents Chemother. 51: 535-542 [Abstract] [Full Text]  
• Gaind, R., Paglietti, B., Murgia, M., Dawar, R., Uzzau, S., Cappuccinelli, P., Deb, M., Aggarwal, P., Rubino, S. (2006). Molecular characterization of ciprofloxacin-resistant Salmonella enterica serovar Typhi and Paratyphi A causing enteric fever in India. J Antimicrob Chemother 58: 1139-1144 [Abstract] [Full Text]  
• Ahmed, D., D'Costa, L. T., Alam, K., Nair, G. B., Hossain, M. A. (2006). Multidrug-Resistant Salmonella enterica Serovar Typhi Isolates with High-Level Resistance to Ciprofloxacin in Dhaka, Bangladesh.. Antimicrob. Agents Chemother. 50: 3516-3517 [Full Text]  
• Turner, A. K., Nair, S., Wain, J. (2006). The acquisition of full fluoroquinolone resistance in Salmonella Typhi by accumulation of point mutations in the topoisomerase targets. J Antimicrob Chemother 58: 733-740 [Abstract] [Full Text]  
• Renuka, K, Sood, S., Das, B. K, Kapil, A. (2005). High-level ciprofloxacin resistance in Salmonella enterica serotype Typhi in India. J Med Microbiol 54: 999-1000 [Full Text]  
• Sierra, J. M., Martinez-Martinez, L., Vazquez, F., Giralt, E., Vila, J. (2005). Relationship between Mutations in the gyrA Gene and Quinolone Resistance in Clinical Isolates of Corynebacterium striatum and Corynebacterium amycolatum. Antimicrob. Agents Chemother. 49: 1714-1719 [Abstract] [Full Text]  
• Hirose, K., Terajima, J., Izumiya, H., Tamura, K., Arakawa, E., Takai, N., Watanabe, H. (2005). Antimicrobial Susceptibility of Shigella sonnei Isolates in Japan and Molecular Analysis of S. sonnei Isolates with Reduced Susceptibility to Fluoroquinolones. Antimicrob. Agents Chemother. 49: 1203-1205 [Abstract] [Full Text]  
• Shakespeare, W. A., Davie, D., Tonnerre, C., Rubin, M. A., Strong, M., Petti, C. A. (2005). Nalidixic Acid-Resistant Salmonella enterica Serotype Typhi Presenting as a Primary Psoas Abscess: Case Report and Review of the Literature. J. Clin. Microbiol. 43: 996-998 [Abstract] [Full Text]  
• Kariuki, S., Revathi, G., Muyodi, J., Mwituria, J., Munyalo, A., Mirza, S., Hart, C. A. (2004). Characterization of Multidrug-Resistant Typhoid Outbreaks in Kenya. J. Clin. Microbiol. 42: 1477-1482 [Abstract] [Full Text]  
• Ling, J. M., Chan, E. W., Lam, A. W., Cheng, A. F. (2003). Mutations in Topoisomerase Genes of Fluoroquinolone-Resistant Salmonellae in Hong Kong. Antimicrob. Agents Chemother. 47: 3567-3573 [Abstract] [Full Text]