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Antimicrobial Agents and Chemotherapy, October 2002, p. 3257-3260, Vol. 46, No. 10
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.10.3257-3260.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

A Resistance-Nodulation-Cell Division Family Xenobiotic Efflux Pump in an Obligate Anaerobe, Porphyromonas gingivalis

Takeshi Ikeda1,2* and Fuminobu Yoshimura1

Department of Microbiology,1 Research Institute of Advanced Oral Science, School of Dentistry, Aichi-Gakuin University, Nagoya 464-8650, Japan2

Received 12 February 2002/ Returned for modification 2 May 2002/ Accepted 24 June 2002

Porphyromonas gingivalis, a gram-negative obligate anaerobe, contains two homologs of an Escherichia coli resistance-nodulation-cell division-type multidrug exporter gene, acrB, in putative operons, together with homologs of membrane fusion protein gene acrA and outer membrane channel gene tolC. MIC determination and accumulation assays with mutants with disruptions of one or more genes showed that one cluster, named xepCAB, pumped out multiple agents including rifampin, puromycin, and ethidium bromide.

* Corresponding author. Mailing address: Department of Microbiology, School of Dentistry, Aichi-Gakuin University, 1-100 Kusumoto-cho, Chikusa-ku, Nagoya 464-8650, Japan. Phone: 81-52-751-2561. Fax: 81-52-752-5988. E-mail: takeshii{at}dpc.aichi-gakuin.ac.jp.

Antimicrobial Agents and Chemotherapy, October 2002, p. 3257-3260, Vol. 46, No. 10
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.10.3257-3260.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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