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Antimicrobial Agents and Chemotherapy, October 2002, p. 3273-3275, Vol. 46, No. 10
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.10.3273-3275.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

In Vitro Activity of the New Oxazolidinone AZD2563 against Enterococci

G. M. Eliopoulos,1,2* C. B. Wennersten,1 and R. C. Moellering Jr.1,2

Department of Medicine, Beth Israel Deaconess Medical Center,1 Harvard Medical School, Boston, Massachusetts 021152

Received 11 March 2002/ Returned for modification 8 May 2002/ Accepted 28 June 2002

The activity of a new oxazolidinone antimicrobial, AZD2563, was assessed against >500 clinical isolates of enterococci representing six species. All isolates, including those resistant to other antibiotic classes, were inhibited by AZD2563 at concentrations <=2 µg/ml, except for four strains resistant to linezolid. In most cases, AZD2563 was twofold more active than linezolid against enterococci.

* Corresponding author. Mailing address: Department of Medicine, Beth Israel Deaconess Medical Center, One Deaconess Rd., Boston, MA 02215. Phone: (617) 632-8586. Fax: (617) 632-7442. E-mail: geliopou{at}caregroup.harvard.edu.

Antimicrobial Agents and Chemotherapy, October 2002, p. 3273-3275, Vol. 46, No. 10
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.10.3273-3275.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Yong, D., Yum, J. H., Lee, K., Chong, Y., Choi, S. H., Rhee, J. K. (2004). In Vitro Activities of DA-7867, a Novel Oxazolidinone, against Recent Clinical Isolates of Aerobic and Anaerobic Bacteria. Antimicrob. Agents Chemother. 48: 352-357 [Abstract] [Full Text]  


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