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Antimicrobial Agents and Chemotherapy, October 2002, p. 3283-3285, Vol. 46, No. 10
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.10.3283-3285.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Comparison of In Vitro Activities of Gatifloxacin and Ciprofloxacin against Four Taxa of Rapidly Growing Mycobacteria

Barbara A. Brown-Elliott,* Richard J. Wallace, Jr., Christopher J. Crist, Linda Mann, and Rebecca W. Wilson

Department of Microbiology, University of Texas Health Center, Tyler, Texas 75708

Received 6 May 2002/ Returned for modification 23 May 2002/ Accepted 9 July 2002

By using current NCCLS broth microdilution methods, we found that gatifloxacin inhibited 90% of the isolates of the Mycobacterium fortuitum group at <=0.12 µg/ml and 90% of the Mycobacterium chelonae isolates at <=4 µg/ml. Gatifloxacin was generally fourfold more active than ciprofloxacin. We recommend that both gatifloxacin and ciprofloxacin be tested routinely against rapidly growing mycobacteria.

* Corresponding author. Mailing address: Department of Microbiology at the University of Texas Health Center, 11937 US Hwy 271, Tyler, TX 75708. Phone: (903) 877-7685. Fax: (903) 877-7652. E-mail: barbara.elliott{at}uthct.edu.

Antimicrobial Agents and Chemotherapy, October 2002, p. 3283-3285, Vol. 46, No. 10
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.10.3283-3285.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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