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Antimicrobial Agents and Chemotherapy, October 2002, p. 3286-3287, Vol. 46, No. 10
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.10.3286-3287.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Carbapenem-Resistant Pseudomonas aeruginosa in Malaysia Producing IMP-7 ß-Lactamase

Siaw Eng Ho, Geetha Subramaniam, Selvi Palasubramaniam, and Parasakthi Navaratnam*

Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia

Received 19 November 2001/ Returned for modification 16 March 2002/ Accepted 19 July 2002

We have isolated and identified a carbapenem-resistant Pseudomonas aeruginosa strain from Malaysia that produces an IMP-7 metallo-ß-lactamase. This isolate showed high-level resistance to meropenem and imipenem, the MICs of which were 256 and 128 µg/ml, respectively. Isoelectric focusing analyses revealed pI values of >9.0, 8.2, and 7.8, which indicated the possible presence of IMP and OXA. DNA sequencing confirmed the identity of the IMP-7 determinant.

* Corresponding author. Mailing address: Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. Phone: 603-79502879. Fax: 603-79584844. E-mail: parasak{at}ummc.edu.my.

Antimicrobial Agents and Chemotherapy, October 2002, p. 3286-3287, Vol. 46, No. 10
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.10.3286-3287.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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