This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Yanagihara, K.
Right arrow Articles by Kohno, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yanagihara, K.
Right arrow Articles by Kohno, S.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, October 2002, p. 3288-3291, Vol. 46, No. 10
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.10.3288-3291.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Efficacy of Linezolid against Methicillin-Resistant or Vancomycin-Insensitive Staphylococcus aureus in a Model of Hematogenous Pulmonary Infection

Katsunori Yanagihara,1,2* Yukihiro Kaneko,1 Toyomitsu Sawai,1 Yoshitsugu Miyazaki,1 Kazuhiro Tsukamoto,1,2 Yoichi Hirakata,1 Kazunori Tomono,1 Jun-Ichi Kadota,1 Takayoshi Tashiro,1 Ikuo Murata,1,2 and Shigeru Kohno1,3

Second Department of Internal Medicine,1 Department of Pharmacotherapeutics, Nagasaki University Graduate School of Pharmaceutical Sciences,2 Division of Molecular and Clinical Microbiology, Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Medical Sciences, Nagasaki, Japan3

Received 12 April 2002/ Returned for modification 31 May 2002/ Accepted 15 July 2002

We investigated the activities of linezolid, vancomycin, and teicoplanin in a murine model of hematogenous pulmonary infection with Staphylococcus aureus. Our results demonstrate that linezolid clearly reduced bacterial numbers in the methicillin-resistant S. aureus hematogenous infection model and significantly improved the survival rate of immunocompromised mice infected with vancomycin-insensitive S. aureus compared with vancomycin and teicoplanin. The pharmacokinetic profiles also reflected the effectiveness of linezolid.

* Corresponding author. Mailing address: Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852, Japan. Phone: 81-95-849-7276. Fax: 81-95-849-7285. E-mail: kyana-ngs{at}umin.ac.jp.

Antimicrobial Agents and Chemotherapy, October 2002, p. 3288-3291, Vol. 46, No. 10
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.10.3288-3291.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Kihara, R., Yanagihara, K., Morinaga, Y., Araki, N., Nakamura, S., Seki, M., Izumikawa, K., Kakeya, H., Yamamoto, Y., Tsukamoto, K., Kamihira, S., Kohno, S. (2008). Potency of SMP-601, a Novel Carbapenem, in Hematogenous Murine Bronchopneumonia Caused by Methicillin-Resistant and Vancomycin-Intermediate Staphylococcus aureus. Antimicrob. Agents Chemother. 52: 2163-2168 [Abstract] [Full Text]  
  • Youssef, S., Hachem, R., Chemaly, R. F., Adachi, J., Ying, J., Rolston, K., Raad, I. (2008). The role of vitamin B6 in the prevention of haematological toxic effects of linezolid in patients with cancer. J Antimicrob Chemother 61: 421-424 [Abstract] [Full Text]  
  • Kohno, S., Yamaguchi, K., Aikawa, N., Sumiyama, Y., Odagiri, S., Aoki, N., Niki, Y., Watanabe, S., Furue, M., Ito, T., Croos-Dabrera, R., Tack, K. J. (2007). Linezolid versus vancomycin for the treatment of infections caused by methicillin-resistant Staphylococcus aureus in Japan. J Antimicrob Chemother 60: 1361-1369 [Abstract] [Full Text]  
  • Ishimoto, H., Mukae, H., Date, Y., Shimbara, T., Mondal, M. S., Ashitani, J., Hiratsuka, T., Kubo, S., Kohno, S., Nakazato, M. (2006). Identification of hBD-3 in respiratory tract and serum: the increase in pneumonia. Eur Respir J 27: 253-260 [Abstract] [Full Text]  
  • Yanagihara, K., Tashiro, M., Fukuda, Y., Ohno, H., Higashiyama, Y., Miyazaki, Y., Hirakata, Y., Tomono, K., Mizuta, Y., Tsukamoto, K., Kohno, S. (2006). Effects of short interfering RNA against methicillin-resistant Staphylococcus aureus coagulase in vitro and in vivo. J Antimicrob Chemother 57: 122-126 [Abstract] [Full Text]  
  • Fortun, J., Martin-Davila, P., Navas, E., Perez-Elias, M. J., Cobo, J., Tato, M., De la Pedrosa, E. G.-G., Gomez-Mampaso, E., Moreno, S. (2005). Linezolid for the treatment of multidrug-resistant tuberculosis. J Antimicrob Chemother 56: 180-185 [Abstract] [Full Text]  
  • Kaneko, Y., Yanagihara, K., Miyazaki, Y., Tsukamoto, K., Hirakata, Y., Tomono, K., Kadota, J.-i., Tashiro, T., Murata, I., Kohno, S. (2003). Effects of DQ-113, a New Quinolone, against Methicillin- and Vancomycin-Resistant Staphylococcus aureus-Caused Hematogenous Pulmonary Infections in Mice. Antimicrob. Agents Chemother. 47: 3694-3698 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»