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Antimicrobial Agents and Chemotherapy, October 2002, p. 3304-3307, Vol. 46, No. 10
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.10.3304-3307.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Simple Method for Assaying Colistin Methanesulfonate in Plasma and Urine Using High-Performance Liquid Chromatography

Jian Li,1 Robert W. Milne,1* Roger L. Nation,1,{dagger} John D. Turnidge,2 Kingsley Coulthard,1,3 and Jason Valentine1

Centre for Pharmaceutical Research, University of South Australia, Adelaide, South Australia 5000,1 Department of Microbiology and Infectious Diseases,2 Department of Pharmacy, Women's and Children's Hospital, North Adelaide, South Australia 5006, Australia3

Received 19 February 2002/ Returned for modification 15 May 2002/ Accepted 2 July 2002

A simple and sensitive high-performance liquid chromatographic method is described for the determination of colistimethate sodium in plasma and urine. The accuracy and reproducibility was within 10.1 and 11.2% with rat plasma and urine, respectively. Several commonly coadministered antibacterial agents do not interfere with the assay.

* Corresponding author. Mailing address: Centre for Pharmaceutical Research, School of Pharmaceutical, Molecular and Biomedical Sciences, University of South Australia, Adelaide, SA 5000, Australia. Phone: 61 8 8302 2335. Fax: 61 8 8302 2389. E-mail: Robert.Milne{at}unisa.edu.au.

{dagger} Present address: Victorian College of Pharmacy, Monash University, Parkville, Victoria 3052, Australia.

Antimicrobial Agents and Chemotherapy, October 2002, p. 3304-3307, Vol. 46, No. 10
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.10.3304-3307.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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