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Antimicrobial Agents and Chemotherapy, October 2002, p. 3311-3315, Vol. 46, No. 10
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.10.3311-3315.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Fluoroquinolone-Resistant Streptococcus pneumoniae Strains Occur Frequently in Elderly Patients in Japan

Shin-ichi Yokota,1 Kiyoshi Sato,1,2 Osamu Kuwahara,3 Satoshi Habadera,3 Naoyuki Tsukamoto,4 Hironori Ohuchi,4 Hirotsugu Akizawa,5 Tetsuo Himi,6 and Nobuhiro Fujii1*

Departments of Microbiology,1 Otolaryngology, Sapporo Medical University School of Medicine, Chuo-ku, Sapporo 060-8556,6 Hokkaido Wako Junyaku Co., Ltd., Kita-ku, Sapporo 001-0015,2 Sapporo Clinical Laboratory, Inc., Chuo-ku, Sapporo 060-0005,3 SRL Hokkaido, Inc., Chuo-ku, Sapporo 064-0919,4 Laboratory Medicine, Hokkaido University Medical Hospital, Kita-ku, Sapporo 060-8648, Japan5

Received 29 April 2002/ Returned for modification 3 June 2002/ Accepted 6 July 2002

We identified and genetically characterized seven fluoroquinolone-resistant Streptococcus pneumoniae strains among 293 clinical strains isolated from 1999 to 2001 in Japan. The resistant strains were isolated only from adults, and 7 of 31 isolates (22.6%) were from patients more than 20 years old. Resistant strains were not found in 262 isolates from children under age 10.

* Corresponding author. Mailing address: South-1, West-17, Chuo-ku, Sapporo 060-8556, Japan. Phone: 81-11-611-2111. Fax: 81-11-612-5861. E-mail: fujii{at}sapmed.ac.jp.

Antimicrobial Agents and Chemotherapy, October 2002, p. 3311-3315, Vol. 46, No. 10
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.10.3311-3315.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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