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Antimicrobial Agents and Chemotherapy, October 2002, p. 3327-3330, Vol. 46, No. 10
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.10.3327-3330.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Inhibition of Secretion of Interleukin-1{alpha} and Tumor Necrosis Factor Alpha by the Ketolide Antibiotic Telithromycin

Fausto G. Araujo,1 Teri L. Slifer,1 and Jack S. Remington2*

Research Institute, Palo Alto Medical Foundation,1 Stanford University Medical School, Palo Alto, California 943012

Received 14 February 2002/ Returned for modification 11 May 2002/ Accepted 24 June 2002

The antibiotic telithromycin was examined for its effect on secretion of interleukin-1{alpha} (IL-1{alpha}), IL-1ß, IL-6, IL-10, and tumor necrosis factor alpha (TNF-{alpha}) by lipopolysaccharide (LPS)-stimulated monocytes of eight human donors. Secretion of each cytokine was significantly increased by LPS alone, whereas treatment with telithromycin significantly inhibited secretion of IL-1{alpha} and TNF-{alpha} but not secretion of IL-1ß, IL-6, and IL-10. Telithromycin had immunomodulatory effects as a result of alteration of secretion of IL-1{alpha} and TNF-{alpha} by monocytes.

* Corresponding author. Mailing address: Research Institute, Palo Alto Medical Foundation, Ames Building, 795 El Camino Real, Palo Alto, CA 94301. Phone: (650) 326-8120. Fax: (650) 329-9853. E-mail: remingtonl{at}pamf.org.

Antimicrobial Agents and Chemotherapy, October 2002, p. 3327-3330, Vol. 46, No. 10
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.10.3327-3330.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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